Formulation of tablet abhi.pptx

A tablet (also known as a pill) is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medication with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid dose. The main advantages of tablets are to ensure a consistent dose of medicine that is easy to consume.tablets
Tablets are prepared either by moulding or by compression.

1. Formulation of tablet Student Name:- Abishek Borkar Class- B- pharm 3 rd year Shraddha Institute of Pharmacy Kondala zambre , Washim-444505

2.  CONTENTS Introduction Formulation of tablet. Method Of Granulation Wet Dry Direct Compressions 4. Reference

3. TABLETS Tablets are solid preparations Consisting of one or more active ingredient Obtained by compressing uniform volumes of particles into various size and shape

4. FORMULATION OF TABLETS Formulation of a tablet requires the following considerations: 1. Size of dose or quantity of active ingredients. 2. Stability of active ingredient(s). 3. Solubility of active ingredient(s). 4. Density of active ingredient(s). 5. Compressibility of active ingredient(s). 6. Selection of excipients. 7. Method of granulation (preparation for compression). 8. Character of granulation. 9. Tablet press, type, size, capacity. 10. Environmental conditions (ambient or humidity control). 11. Stability of the final product. 12. Bioavailability of the active drug content of the tablet.

5. Granulation Granulation is the process in which powder particles are made to adhere to form larger particles called granules. Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on their subsequent use . Reasons for granulations: To prevent segregation of the constituents in the powder mix. To improve the flow properties of the mix. To improve the compression characteristics of the mix.

6. Wet Granulation – [ Aqueous Granulation Technique ] The purpose of wet granulation is to convert the drug and excipient mixture into granules that flow well into dies, and which are compressible into mechanically strong and acceptable tablets

7. PROCESS OF wet GRANULATION Premixing drug with other ingredients using a V-shaped mixer. Transferring the mixture into a traditional low shear granulator where a binder solution is added under a mechanical shear until a certain granule size and binding are obtained. Wet sieving of granules through a desired screen size. Drying of granules in a tray-oven dryer. Dry sieving/milling of granules to a certain particle size distribution. Adding a lubricant to the dry granules. Compressing the granules into tablets.

8. Dry Granulation – [ Non- Aqueous Granulation Technique ] After the process of granulation, the product exists as a wet mass from which the liquid must be removed. Water is usually removed by evaporation for which energy is needed. SEIVING :- When the drying process is complete, it is likely that the product will have cohered into relatively large masses, especially if tray drying has been used. The dried material is therefore passed through a sieve (usually 250– 700 mm) to break up aggregates and to give a relatively uniformly sized granules.

9. PROCESS OF DRY GRANULATION Premixing drug with other ingredients using a V-shaped mixer. Transferring the mixture into a roller compactor using a closed-circuit vacuum equipment to prevent dust formation. Milling/sieving of the resulting flakes or ribbons into granules. Adding lubricant and/or disintegrant to granules, and finally. Compressing the granules into tablets.

10. DIRECT COMPRESSION The name implies, this method involves no further processing of powders before tableting. A formulation is well mixed to ensure uniform drug distribution, and after adding a lubricant, tablets are compressed .

11. PROCESS OF DIRECT COMPRESSION Premixing drug with other ingredients using a V-shaped mixer Adding a lubricant to the granules Mixing with lubricant 3 to10 minutes Compressing the granules

12. References A Text Book Of Industrial Pharmacy– I By Nirali Prakashan page no 42-61. A theory and practical book of Industrial Pharmacy fourth edition by lackman / libreman page no 449-543.