Furosemide

Furosemide drug

1. Furosemide

2. Diuretics : Diuretics, also called as water pills, are medications designed to prevent the body from absorbing too much salt and to increase the amount of water and salt to expell from the body as urine. They’re often prescribed to help treat high blood pressure.

3. Furosemide : Furosemide is a type of medicine called a diuretic. Furosemide is used to reduce extra fluid in the body ( edema ) caused by conditions such as heart failure, liver disease and kidney disease. Furosemide – high ceiling. They are organic compounds containing a benzenesulfonamide with an amine group attached to a benzene ring.

4. Pharmcokinetics : Absorption: 60-67% absorbed after oral administration . Protein Binding: 91-99%. Metabolism: Minimally metabolized liver, some nonhepatic metabolism . E xcretion: via kidney by glomerular filtration of tubular secretion. H alf-life: 30-60 min

5. Mechanism of action : Kidney contains 1 million nephrons. These nephrons filters and balance fluids and electrolytes between the blood and urine. Water and other molecules are filtered from the blood by the Glomerulus. And the water and other molecules are reabsorbed by the proximal convulated tubule, loop of henle and collecting duct. And the excess amount of filterate is passed as urine.

6. Mechanism of action : Loop diuretics inhibit the body's ability to reabsorb sodium at the ascending loop in the kidney which leads to a retention of water in the urine . No transport systems in descending loop of henle. Inhibits Na-K-2Cl transporter in thick ascending loop of henle . Competes with Cl-binding site

7. Therapeutic uses : Furosemide is used to reduce extra fluid in the body (edema) caused by conditions such as heart disease, kidney failure and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. It is also used to treat high blood pressure.

8. Side effects : Headache Dizziness T hirst In creased blood sugar M uscle cramps Increased cholesterol Skin rash Gout Diarrhoea