Gall bladder cancer or carcinoma related to gall bladder

It is about tha carcinoma of gall bladder.

1. GALL BLADDER
CARCINOMA
Submitted to:-Dr.SeemaAhlawat
Submitted by:-Lakshmi Joshi
B.Sc. (H) Nursing Semester IV

2. INTRODUCTION
▪Gall bladder cancer is the 5
th
most common
type of cancer involving the GI tract, but it is
the most common malignant tumorof the
biliary tract worldwide.

3. DEFINITION
▪Carcinoma of gall bladder is a frequent
malignant tumorof the biliary tract.
▪It is more frequent in the female with peak
incidence in the seventh decade of life.
▪The average age of gall bladder carcinoma is
65 years.

4. EPIDEMIOLOGY
▪Cancer gall bladder is rare, constituting less than 1% of all cancer cases .
▪It is usually found coincidentally in patients with cholecystitis.
▪It is rapidly progressing and usually fatal.
▪Patients seldom live 1year after the diagnosis.
▪The poor prognosis is usually because of late diagnosis

5. ▪Many consider gallbladder cancer a complication of
gallstones. This inference rests on circumstantial
evidence from postmortem examinations.
▪60% to 90% of all gallbladder cancer patients also
have gallstones.
▪Postmortem data from patients with gallstones show
gallbladder cancer in only 0.5%.
▪Adenocarcinoma accounts for 85% to 95% of all cases
of gallbladder cancer; squamous cell carcinoma
accounts for 5% to 15%.
▪Mixed-tissue types are rare.Lymphnode metastasis is
present in 25% to 70% of patients at diagnosis.

6. CLINICAL MANIFESTATIONS
▪Pain
▪Jaundice
▪Noticeable mass
▪Anorexia
▪Weight loss
▪Intense pruritis
▪Metastasized growth to adjacent organs

7. PATHOLOGICAL CHANGES
▪Irregular area of diffuse thickening and
induration of gall bladder wall.
▪Deep ulceration in the wall of gall bladder.
▪Friable, papillary or cauliflower like growth
▪Invasion of gall bladder wall and liver bed.

8. DIAGNOSTIC METHODS
▪CT scan
▪Ultrasound
▪USG guided FNAC
▪Biopsy
▪Liver function tests

9. ETIOPATHOGENESIS
▪Cholelithiasisand cholecystitis, Chemical
carcinogens and Genetic factors.
▪Miscellaneous parents who have undergone
previous surgery on the biliary tract, inflammatory
bowel disease.
▪Genetic mutations and disruption of normal cell
growth.
▪May lead to gall bladder carcinoma.

10. TREATMENT
▪Cholecystectomy
▪Gall bladder cancer is generally
unresponsive to other therapies , the presence
of any residual disease after any surgical
intervention predicts poor outcome.

11. THANK YOU