General Pathology and Oncology hfjjcfh.pdf

General Pathology and Oncology hfjjcfh.pdf

1. GENERAL VETERINARY
PATHOLOGY AND ONCOLOGY
Dr.J.SELVARAJ
Professor and Head
Department of Veterinary Pathology
VCRI, Orathanadu

2. ANOMALY -AMELIA -FOAL

3. MONSTER –DOUBLE HEADED
(Dicephalusbicollis)–CALF

4. Bacillus anthracis-Anthrax

5. Necrotic hepatitis -Pasteurellosis Liver impression smear -Bipolar organisms
–Leishman’s stain
Bacteria-Pasteurellamultocida

6. Aspergillusfumigatus

7. Organ?
Eye
Lesion?
Scleralvessels hyperaemic

8. Species?
Human
Organ?
Legs
Lesion?
Swollen legs -pits on pressure
Morphologic diagnosis?
Dependent oedemaof legs

9. Animal: Rat
Organ?
Lung
Lesion?
Eosinophilicfluid distending the alveoli in the lower specimen
Morphologic diagnosis?
Pulmonary oedema

10. Pulmonary congestion and oedema

11. PETECHIAE –Epicardiumof heart

12. Animal: Dog
Organ?
Heart with pericardium
Lesion?
Pericardial sac is filled with blood clot
Morphologic diagnosis?
Haemopericardium–Cardiac tamponade
Sequelae?
The dog may die suddenly

13. Apoplexy
Brain -Congestion

14. Animal: Bovine
Organ?
Heart
Lesion?
Dry lusterless pale clot (thrombus) is seen attached to the valves.
Morphologic diagnosis?
Vegetative valvularendocarditis
Aetiology?
Arcanobacterium& Streptococci are most common -Bovine

15. Organ?
Kidney
Lesion?
Renal glomerulicontains blue bacterial colonies
Morphologic diagnosis?
Renal glomerularseptic emboli

16. Animal:Dog
Organ?
Kidney
Lesion?
A reddish triangular area with base towards the cortical
surface seen. The base of lesion is slightly elevated than
the normal area
Morpholoigcdiagnosis?
Renal red infarct

17. Organ?
Spleen
Lesion?
Spleen has mutiplepale triangular areas
Morphologic diagnosis?
Splenicpale infarct

18. CYSTIC ENDOMETRIAL HYPERPLASIA –UTERUS -
BITCH

19. Animal:Dog
Organ? Kidney
Lesion?
Left side kidney is smaller and cortex
is irregular
Morpholoigcdiagnosis?
Unilateral hypoplasiaof the left
kidney
HYPOPLASIA

20. Organ?
Heart
Lesion?
Left ventricular wall is much thicker
Morphologic diagnosis?
Left ventricular hypertrophy

21. Fatty changes

22. Organ?
Spleen
Lesion?
Spleen cut surface has multifocal pale
round areas -looks like Sago –sago spleen
Morphological diagnosis?
Spleen, amyloidosis, multifocal

23. Animal?
Poultry
Organ?
Heart with pericardium
Lesion?
Pericardium is covered with chalky white deposits; Needle shaped
crystals seen.
Morphological diagnosis?
Visceral gout
Pathogenesis?
Deposition of urates(insoluble crystalline uric acid salts)

24. Lesion?
Left side lung alone is congested
Why?
It is the pooling of blood in capillaries and veins in a dependent part
due to the effect of gravity. It is seen most commonly in sick animals
that are in a recumbent position for a long time. These lungs are
from a pig that was paralyzed due to a brain abscess. It was
recumbent for two days prior to death.
Morphologic diagnosis?
Hypostatic congestion -Lungs

25. Ballooning of intestine-Postmortem change -Goat

26. Organ?
Brain
Lesion?
Meningesin a focal area shows blackish discolouration
Morphologic diagnosis?
Melanosisof meninges

27. Animal?
Dog
Organ?
Oral mucosa
Lesion?
Oral mucosa is yellowish
Morphologic diagnosis?
Ictericoral mucosa

28. Animal: Chimpanzee
Organ? Lung
Lesion?
Lung is having blackish pigmentation -peppered appearance
Morphologic diagnosis?
Pulmonary anthracosis

29. Organ?
Gums and bones
Lesion?
Gums show blue line
Metaphysealplate of growing long bones (“lead lines”) show an
increased density
Aetiology?
Lead poisoning/ Plumbism

30. LANGHAN’S GIANT CELLS

31. History: Microscopic picture of Hodgkin’s disease
What type of cell do you see at the centre?
It has twin nuclei which are mirror image of the other -
Reed –Sternberg cell.

32. Animal: Calf
Organ? Intestine
Lesion?
Note the mucosal congestion and yellowish colourof the intestinal
contents, in which fibrin fragments can be identified. On the right,
the intestinal contents have been removed and the congested
mucosa is readily seen
Morphologic diagnosis?
Acute enteritis

33. Animal:Bovine
Organ? Small intestine
Lesion?
Pseudomembranesattached to the mucosa of intestine
Morphologic diagnosis?
Diphtheritic enteritis
Disease?
Salmonellosis

34. Animal: Bovine
Organ? Lung
Lesion?
Lung is covered with white fibrinousmaterial. Lung is diffusely dark reddish brown in
colour.
Morphologic diagnosis?
Fibrinouspleuropneumonia

35. ABSCESS –SKIN –PIG

36. Animal: Bovine
Cavity? Thoracic cavity
Lesion?
Thoracic cavity is filled with pus
Morphologic diagnosis?
Pyothorax

37. Organ?
Intestine
Lesion?
Intestinal epithelium has many gobletcells; Mucosal congestion;
Lumen contains bluish stained mucus.
Morphologic diagnosis?
Catarrhal enteritis

38. Organ: Skin
Lesion?
The skin surface has re-epithelialized, and below this is
granulation tissue with small capillaries and fibroblasts
forming collagen.
Morphologic diagnosis?
Re-epithelializedgranulation tissue

39. Animal?
Horse
Organ?
Left hind limb
Lesion?
Left hind limb below the hock has
a large proliferating mass with no
skin covering
Morphologic diagnosis?
Exuberant granulation tissue or
proud flesh
Aetiology?
Sometimes the granulation
continues to grow in abnormally
large amount due to irritant,
movement or trauma which
prevents healing.

40. Animal? Sheep
Organ? Face and ear
Lesion?
Face skin is erythematous
Ear is partly sloughed
Morphologic diagnosis?
Photosenstizationaldermatitis

41. Microtome

42. Canine lupus erythematosus
Aetiology:Platelet destruction (autoantibodiesto platelets)
leading to thrombocytopenic purpura
Lesion:Petechiaeand ecchymosesin the skin and mucous
membrane.
Lymphocytic infiltration is seen around the dermal blood
vessels of dogs.
Condition: Canine systemic lupus erythematosus

43. Papilloma
Animal?Bovine
Organ?Skin
Lesion?Greyishblack irregular elevated cauliflower
like nodules (Warts) seen
Aetiology?Papillomavirus
Morphologic diagnosis? Bovine cutaneous
papillomatosis
Squamousepithelium is thickened with many
finger like projections. Under the epithelium
there is a connective tissue core.

44. Squamouscell carcinoma
Nasal planumof cat
Lesion?Cell nests seen with keratin pearls at the
centre surrounded by squamouscells
Morphologic diagnosis? Squamouscell carcinoma

45. Malignant melanoma
Bullock-Hind Leg
Melanocytesare more, irregular and
contain brownish pigments

46. Mammary gland adenocarcinoma
Irregular acini, multilayered epithelium
with luminal projections