Gentamicin

gentamicin drug description

1. Gentamicin

2. Trade Name GENTICYN ( Reckitt Benckiser) Available in Paediatric inj: 10mg/ml; 2ml vial Inj: gentamycin as sulphate: 40mg/ml; 1ml and 2ml amp. GENTICILLIN ( Indus Pharma) Inj 20mg/40mg/80mg: Per amp: Gentamycin(as sulphate) 20mg(2ml amp)/40mg(1ml amp/80mg(2 ml amp) GENTALEK (Novartis) Inj 80mg: Per amp; gentamicin sulphate 80mg(2ml amp) GENTAMED (Munawar Pharma) Inj 80mg: Per amp; gentamicin sulphate 80mg(2ml amp) GENTIC (Bosch) Inj: of 10mg/20mg/40mg/80mg/160mg are available.

3. Generic Name Gentamycin sulphate

4. Name Of the Manufacturer Reckitt Benckiser Pakistan Ltd: Owned By: Reckitt Benckiser Group PLC Y.E.O: 1958 Type: Manufacturers Specialization: Household , Consumer and Pharmaceutical Products Chief Executive: Ali Ahmed Khan

5. Drug Catgory Aminoglycoside Anti-infective Protein synthesis inhibtors

6. Contents Paediatric inj : Gentamycin (as sulphate) 10mg/ml; 2ml vial Inj : Gentamycin (as sulphate) 40mg/ml; 1ml & 2ml amp.

7. Mode Of Action Abnormal codon - Anticodon leads to misreading of the message. Gentamycin inhibit protein synthesis of bacteria. Susceptible organisms have an oxygen dependent system that transport the antibiotic across the cell membrane. The antibiotic then binds to the separated 30S ribosomal subunit, interfering with the assembly of the functional ribosomal apparatus or causing the 30S subunit of the complete ribosome to misread the genetic code. Polysomes become depleted because gentamycin interrupt the process of polysome disaggregation and assembly.

8. Indications Serious gentamicin sensitive infections. UTI Tularemia Infections due to Enterococci Infections due to Pseudomonas aeroginosa

9. Dosage Adults : up to 5mg/kg IM or IV daily in three divided doses for 7-10 days. Children : -up to 2 weeks, 3mg/kg 12 hourly -0ver 2 weeks, 2mg/kg 8 hourly -Both IM or IV for 7-10 days

10. Contra-ind : Pregnancy Precautions: Myasthenia gravis, Parkinsonism. Monitor serum levels as over 10 micrograms/ml can cause vascular toxicity and renal impairment. Interactions: Neuromascular blocking drugs, anesthetic, ethacrynic acid and frusemide.

11. Adverse Drug Reactions Ototoxicity Nephrotoxicity Neuromascular paralysis Allergic reactions

12. Storage Conditions Store in air-tight containers. The potency of gentamicin sulphate is lost in plastic disposable syringes and a brown precipitate is formed . Storage in glass disposable syringes should not exceed 30 days

13. Cloxacillin

14. Trade name ORBENIN (GSK) Caps 250mg: cloxacillin (as sodium salt) 250mg. Inj 250mg: cloxacillin 250mg; vial Syp: Per 5ml: cloxacillin 125mg; after reconstitution as per dir. AUROPEN CIRIN PHARMACEUTICALS (PVT) LTD . CLOXALITE ELITE PHARMA CLOXAZAN ZAFA PHARMACEUTICAL LABORATORIES (PVT ) CLOXIN WILSONS PHARMACEUTICALS VENAL GEOFMAN PHARMACEUTICALS

15. AMPICLOX (GSK) Caps 250mg:Ampicillin 125mg, cloxacillin 125mg Drops Neonatal:per 0.6ml:ampicillin 60mg, cloxacillin 30mg Inj 250mg/500mg:ampicillin 125mg/250mg,cloxacillin 125mg/250mg.syp:Per 5ml,ampicillin 125mg,cloxacillin 125mg PECLOX (Lowitt) Susp:Per 5ml; ampicillin 125mg,cloxacillin 125mg Inj 500mg: ampicillin 250mg, cloxacillin 250mg

16. Drug Category Penicillinase-resistant penicillin

17. Contents Caps 250mg: cloxacillin (as sulphate) 250mg Inj 250mg: cloxacillin 250mg ; vial Syrup : per 5ml: cloxacillin (as sulphate) 125mg; after reconstitution as per direction mentioned on the pack

18. Name of the manufacturer GlaxoSmithKline Pakistan Limited: GlaxoSmithKline Pakistan Limited was created January 1st, 2001 through the merger of SmithKline and French of Pakistan Limited, Beecham Pakistan (Private) Limited and Glaxo Wellcome (Pakistan) Limited- standing today as the largest pharmaceutical company in Pakistan. As an industry leader they are committed to mission of providing patients quality products to help improve their lives

19. Mode of Actions Exerts bactericidal activity via inhibition of bacterial cell wall synthesis by binding one or more of the penicillin binding proteins (PBPs). Exerts bacterial autolytic effect by inhibition of certain PBPs related to the activation of a bacterial autolytic process.

20. Indications Bacterial infections Respiratory tract infections Septicaemia Soft tissue infections Bone and joint infection Endocarditis Skin infections Meningitis associated with spina bifida Enterocolitis Cystitis

21. Doses Caps/Syp: Adults: 500mg six hourly. Children: Under 2 years; quarter adult dose. Over 2 years; half adult dose Injection: Adults: 250mg IM four to six hourly Children: Under 2 years; quarter adult dose. Over 2 years; half adult dose.

22. Adverse Drug Reactions Hematologic: neutropenia, inhibition of platelet aggregation CNS: seizures Hepatic: transient increases in transaminases Other: Jarisch-Herxheimer Reaction (fever, chills, sweating, tachycardia, hyperventilation, flushing , and myalgia)

23. Contraindications: Anaphylaxis to cloxacillin or other penicillins Precautions : Cephalosporin hypersensitivity Drug Interactions: Contraceptives - decreased contraceptive effectiveness Live Typhoid Vaccine - decreased immunological response to the typhoid vaccine Probenecid - increased cloxacillin levels Warfarin - decreased anticoagulant effectiveness

24. Storage Conditions Preserve in tight containers Store at temperature not exceeding 25°C