Gestational hypertension -antihypertensive drugs.

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1. ANTIHYPERTENSIVE DRUGS Here are the choice of drugs given during pregnancy are:- Alpha and Beta blockers- Labetalol hydrochloride calcium channel blockers-Nifedipine alpha blockers-Methyldopa vasodilators-Hydralazine hydrochloride

2. Labetalol Hydrochloride Preparation Injection-5mg/ml in 2oml vial Tablets- 100mg, 2 00 mg ,300mg Action Reduced peripheral vascular resistance as a result of alpha and beta blockade.

3. Adverse effects Dizziness Fatigue Nausea or vomiting Headache Vertigo Dosage and route of administration 50mg or 100mg tablet OD orally 20mg/20ml Inj IV bolus wait for 10min if no response then give 40mg slow bolus .

4. NIFEDIPINE Preparations Capsule-10mg,20mg Tablet-20mg,30mg,60mg,90mg Action Thought to inhibit calcium ion reflex across cardiac and smooth muscle cells, decreasing contractility and oxygen demand and also dilates arteries and arterioles . Dosage and route of administrations 5-20mg OD orally.

5. METHYLDOPA Preparations Tablet-250mg,500mg Inj-50mg/ml Action Inhibit the central vasomotor centre, decreasing sympathetic outflow to the heart, kidney and peripheral vasculature . Dosage and routes of administration 250mg BD or TDS max 2g daily titrated by BP

6. Hydralazine Hydrochloride Preparation Inj-20mg/ml in 1ml vial Tablet-10mg,25g,50mg,100mg Action Direct acting peripheral vasodilator that rel a xes arteriolar smooth muscle . Dosage and route of administration 25mg tablet BD and if necessary may increase to 50mg BD 5mg diluted in 10ml of NS slow IV at 15-20minutes interval.