Gluconeogensis

shubhratmaheshwari 180 views 16 slides Jul 05, 2021

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Gluconeogenesis- Pathway and its significance.

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Gluconeogenesis
Presented by Shubhrat Maheshwari

Gluconeogensis

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Significance of Gluconeogenesis
Glucoseoccupiesakeypositioninthemetabolismandits
continuoussupplyisabsolutelyessentialtothebodyfora
varietyoffunctions
1.Brainandcentralnervoussystem/erythrocytes,testesand
kidneymedullaaredependentonglucoseforcontinuous
supplyofenergy.Humanbrainalonerequiresabout120gof
glucoseperday,outofabout160gneededbytheentirebody.
2.Glucoseistheonlysourcethatsuppliesenergytothe
skeletalmuscle,underanaerobicconditions.
3.lnfastingevenmorethanaday,gluconeogenesismust
occurtomeetthebasalrequirementsofthebodyforglucose
andtomaintaintheintermediatesofcitricacidcycle.Thisis
essentialforthesurvivalofhumansandotheranimals.
4.Certainmetabolitesproducedinthetissuesaccumulatein
theblood,e.g.lactate,glycerol,propionateetc.
Gluconeogenesiseffectivelyclearsthemfromtheblood.