Gpat important questions with answers

GPAT 2020
BPHARM
MPHARM
IMPORTANT QUESTIONS
GPAT PREPERATION

1. GPAT PREPERATION – 2020 PART - 1 IMPORTANT QUESTIONS EXPECTED IN GPAT 2020

2. Prepared by :- M r. K u m a r a n . ,B . P ha r m., Lecturer Dept . of Pharmaceutical Analysis G.P Pharmacy college,Jolarpet, Tirupattur district,Tamil Nadu . CONTACT:- Email – [email protected] *GPAT PASSED AT 2019*

3. GPAT 2020 PART – 1 Each question carries 4 marks for correct answers and -1 marks for incorrect answers. ( 1 25 × 4 = 5 00 ) 1. Human blood is a viscous fluid due to Platelets in plasma Proteins in blood RBC and WBC in blood Sodium in serum 2. Ifosfamide belongs to which group of anticancer drugs Alkylating agents Anti metabolites Mitotic inhibitors Topoisomerase inhibitors 3. Nitrosoureas used in the treatment of cancer are Carmustine 5FU Methotrexate Cisplatin 4. An antidote of cyanide poisoning is Atropine Sodium thiosulphate Dimercaprol Naloxone 5. Proof strength of 90% v/v alcohol is 57.77 % under proof 57.77 % over proof 47.77 % over proof 47.77 % under proof 6. Doxaprem is a Anti-epileptic Antidiabetic Expectorant Respiratory stimulant 7. Glucose is described A monosaccharide A disaccharide A polysaccharide An oligosaccharide

4. 8. Lithium is absolutely contraindicated in Lactation Jaundice Diabetes Typhoid 9. Rancidity of a fat is due to Oxidation Saponification Hydrolysis Neutralisation 10. Antidote of organo phosphorous poisoning is Physostigmine Pralidoxirne Neostigmine Tubocurarine 11. Phenobarbitone is a Sedative Antipsychotic Antiphychotic Anxiolytic 12. Immunoglobin with shortest half life is Ig E Ig A Ig D Ig M 13. One among the following is a communicable disease Cancer Diabetes Hypertension Filariasis 14. The members of DTAB holds the office for years. 3 5 8 2 15. Ingestion of which of the following vitamins should be avoided by a patient taking an oral anticoagulant: Vitamin A Vitamin B Vitamin K Vitamin E

5. 16. Which portion of heart receives oxygenated blood Left auricle Right auricle Left ventricle Right ventricle 17. The recommended illumination required for casual reading is 50 lux 100 lux 300 lux None of the above 18. Power to prohibit into India of any poison except under license State government Drug controller Parliament Central government 19. " BEAUTY VITAMIN " is Vitamin K Vitamin A Vitamin C Vitamin E 20. The Central Drugs Laboratory is located at Izatnagar Kasauli Kolkata Lucknow 21. Interferon are synthesized in response to Mycoplasma Bacteria Fungi Virus Year of an irresolute war between India and Pakistan that led to ‘Tashkent Pact’ between the two countries: (a) 1971 (b) 1965 (c) 1972 (d) 1966 Mechanism of action of GABA is on G-protein Tyrosine kinas PIP/DAG 5- HT

6. 24. The steroid nucleus present in testerone is Androstane Estrane Pregestane Cholestane 25. The Medulla Oblongata is a part of human Heart Brain Liver Sex Organ 26. Western blot test is used for confirmation of Typhoid HIV Cancer Malaria 27. Deadly night shade leaf is synonym of: Senna Vasaka Belladona Datura 28. "DIGITALIS" is used as Cardiotonic Purgative Sedative Smooth muscle relaxant 29. ASPIRIN " is Acetyl salicylic acid Benzoyl salicylic acid Chloro benzoic acid Anthranilic acid 30. Which angiotensin-II receptor blocker is used in hypertension? Valsartan Amlodipine Atenolol Enalapril 32. The vitamin essential in tissue culture medium is: Pyridoxine Thiamine Nicotinic acid Inositol

7. 33. Blood vessels taking from the lungs to the heart are Pulmonary artery Aorta Portal veins Pulmonary veins 34. Mechanism of action of Clindamycin is inhibition of Protein synthesis DNA gyrase Lysosomal enzyme Cell wall synthesis 35. What is "ALZHEIMER'S" disease It affects liver It affects Kidney It affects human immune system It is a disorder of the brain 36. Which two hormones are released from the posterior lobe of the pituitary gland ADH and GH ACTH and TSH ADH and oxytocin TRH and CRH 37. Cetrizine is a active metabolite of Hydroxyzine Promethazine Cimetidine Cinnarizine 38. Common transmission of Aids is Sexual Intercourse Blood Transfusion Placental transfusion All 39. Proton pump inhibitors Omeprazole Trimethaphan Pirenzepine Ranitidine 40. HLB system is used to classify Surfactants Preservatives Antioxidants Squestering agents

8. 41. Absorption of a drug is effected by- Solubility Route of administration Vascularity All of the above 42. The popular drug "LOSARTAN" belongs to which class of Antihypertensive Drugs ACE Inhibitor Angiotensin-II Antagonist Calcium Channel Blocker Renin Inhibitor 43. Hemp is pericyclic fibers obtained from the stem of Linumusitatissimum Corchorousolitorius Cannabis sativa Gossypiumherbaceum 44. Which of the following is formula of Gibb’s phase rule F= C+P+1 F=C-P+2 F=P-C+1 F= P+C+1 45. Which of the following is a synthetic sweetener Glucose Sorbitol Aspartame Sucrose 46. Pellagra is due to the deficiency of Niacin Thiamine Vitamin B12 Vitamin C 47. The phase rule was first discovered by Nernst Gibbs Arrhenius Le Chatelier 48. Fibrinolytic that is antigenic Streptokinase Urokinase Altepase Cholesterol

9. 49. Pickup element that prevents the development of dental carries Sodium Calcium Fluorine Phosphorous 50. Which of the following antibiotic is not produced by bacteria Penicillin Streptomycin Tetracycline Bacitracin 51. A license from licensing authority is not required for sale of the homeopathic medicines generic drugs cosmetics OTC drugs 52. Drug causing gynecomastia is Spironolactone Rifampicin Penicillin Bumetanide 53. Neostigmine is used in the following except Myasthenia gravis Cobra bite Atony of bladder Glaucoma 54. Digitalis toxicity is observed with K⁺ supplementation Ca²⁺ supplementation Increased parasympathetic activity Increased adrenocoticosteroid levels 55. The Schedule in drugs and Cosmetics, Act that deals with the requirements and guidelines for clinical trails, import and manufacture of new drugs is Schedule ‘O’ Schedule ‘M’ Schedule ‘F’ Schedule ‘Y’ 56. Simethicone is component of several antiacid formulations, chemically it is Wax Fat Aldehyde Silicon

10. 57. Alcuronium is semi synthetic derivative with properties of Gallamine Pancuronium Succinylcholine D-tubocurarine 58. Epsum salt is: Sodium sulphate Magnesium sulphate Potassium sulphate None of above 59. In a prescription “STAT” means At once Single tablet at a time Straight Stop after some time 60. Which of the following drug is for treatment of breast cancer Tamoxifen citrate Methotrexate Vinblastin Cisplatin 61. The opium that has been processed to conform to the pharmacopoeia requirements is called ……. Prepared opium Crude opium Medicinal opium Diacetylmorphine 62. Which among the following hydrocarbon have two double bonds and one ring, found in oil Pinene Limonene Borneol Myrcene 63. Heart beat less than 60 beats/mt. is regarded as Bradycardia Tachycardia Hypotension Hypertension 64. The drug used for tuberculosis include all except Dapsone Rifampicin Ethambutol Isoniazid

11. 65. Artesunate is Antiviral drug Antimalarial drug Antifungal drug Anticancer drug 66. Digitalis toxicity is enhanced by co-administration of which of the following? Quinidine Potassium Calcium Diuretics 67. Antisleep pills are made up off Barbiturate BZD Amphetamine Both A & B 68. First political drama of kerala Ritumati Pattabakki Aphante Makal Thozil Kendrathilekku 69. Example of both exocrine & endocrine Liver Spleen Adrenal Pancreas 70. Chewable tablet does not contain Disintegrant Binder Sweetener Lubricant 71. Goitre is caused by Excess secretion of thyroxin Deficiency of iodine Over eating Defective growth hormone 72. Dapsone is - Anti cancer drug Anti viral drug Anti fungal drug Anti leprosy drug

12. 73. .............Is Known as father of medicine Aristotle Dioscorides Hippocrates Galen 74. Glycolysis is a Catabolic pathway Anabolic pathway Amphibolic pathway Fermentation pathway Medical Termination of Pregnancy (MTP) Act was passed in the year (a) 1963 (b) 1980 (c) 1971 (d) 1974 During diastole Blood leaves ventricle Blood leaves heart Blood enters in heart Blood enters lungs 77. Peri-winkle is a common name for: Digitalis purpurea Atropa belladonna Catheranthus roses Datura metal 78. Neuroleptics are used to treat: Neurosis Psychosis Narcolepsy Parkinsonian disorders 79. Minimum age limit for registration as pharmacist is 18 years 21 years 19 years 25 years 80. The membraneous covering of the heart is Meninges Pericardium Pleura Peritoneum

13. 81. Vitamin D3 is also known as Ergocalciferol Cholecaliferol Calciferol Cholesterol 82. Preferred route of insulin is Oral Subcutanious Sublingual Enteric Coated tablets 83. Which disease is caused by virus Polio T.B. Malaria Leprosy 84. The competitive antagonist of Benzodiazepine receptors Flumazenil Picrotoxin Zolpidem Temazepam 85. Itai-Itai disease is caused by Mercury Lead Cadmium Iron 86. Therapeutic drug monitoring is done for Aspirin Chlorpromazine Lithium Statins 87. Tablet Dissolution Test is an indirect measure of Bioavailability Hardness Friability Tablet Shape 88. Causative agent of bacillary dysentery: Shigella E.Coli Proteus Vibrio

14. 89. Disinfectant fluids come under Schedule O Schedule R Schedule S Schedule E 90. The hypotensive effect of clonidine is due to its action on β -adrenergic receptor α -adrenergic receptor H2 -receptor H1 receptor 91. Drugs used to aid digestion in the git Pepsin Probucol Gugulipid Pectin 92. Furosemide is Loop diuretics Osmotic diuretics Thiazide diuretics Potassium sparing diuretics 93. Which of the following is communicable disease Diabetes Hypertension Kwashiorkor Diphtheria 94. Sweling factor is cricria for me purity of Acacia Tragacanth Guar Isopgol 95. Suppositories used for ear infection are called Rockets Cones Bougies Pessaries 96. Number of bones in skull are 18 bones 22 bones 25 bones 28 bones

15. 97. On an average a normal healthy woman should gain about ….. kg of weight during pregnancy 5 kg 12 kg 20 kg 30 kg 98. Dragendorff’s reagent is employed for the identification of Carbohydrates Alkaloids Flavonoids Proteins 99. Deficiency of vitamin C can lead to Dermatitis Lips fissure Scurvy Rickets 100. Dissolution of a drug particle is described by Noyes-Whitney equation Stock’s equation Drag’s equation None 101. Which of the following packaging material is protect the drug content against light Plastic containers Amber colored glass containers Both None 102. The salt intake per day should be kept to a limit of 1 gm daily 5 gm daily 10 gm daily 15 gm daily 103. Ribosomes helps in Protein synthesis Photosynthesis Lipid synthesis Respiration 104. Safest anti-tuberculosis drug in renal disease is Ethambutal Streptomycin Rifampicin Capreomycin

16. 105. Anaphylactic shock occur due to, Allergic reactions Blood loss Spinal cord injury Infections 106. Choose the appropriate therapeutic use of imipramine Insomnia Epilepsy Bed wetting in children Mania 107. A substance used to measure the glomerular filtration rate is Insulin Inulin Diodrast Paraamino hippuric acid 108. Highest amount of solid content present in Ointment Gel Jellies Paste 109. The drug "ALISKERIN" belongs to which class of Antihypertensive Drugs ACE Inhibitor Angiotensin-II Antagonist Calcium Channel Blocker Renin Inhibitor 110. What is Action of digitalis Anti-emetic Analgesic Increase force of contraction of heart Negative ionotropic effect 111. Pellagra is due to the deficiency of Niacin Thiamine Vitamin B12 Vitamin C 112. Cascade impactor is used for determination of Flash point Sedimentation rate Particle size Density of liquid

17. 113. The plant which shows hypoglycemic effect due to indirect stimulation of insulin secretion by pancreas is…….. Strychnos nuxvomica Gingko biloba Gymnema sylvestre Lawsonia inermis 114. Dettol comes under Schedule N Schedule O Schedule P Schedule Q 115. Enzyme which is used in the treatment of leukaemia: Urokinase Streptokinase Asparginase Pepsin 116. Derivatisation of a sample in GC is carried out to Reduce polarity of the analytes Increase the detector response Increase volatility of the analytes All of the above 117. Virginian prune bark is known as Cinchona Wild cherry Kurchi Ashoka 118. The most effective antidote for belladonna poisoning is Neostigmine Physostigmine Pilocarpine Methacholine 119. Type of Rh antibody: IgM IgG IgE IgA 120. Myasthenia gravis is diagnosed with improved neuromuscular function by using Donepezil Edrophonium Atropine Pancuronium

18. 121. Antidote for nicotine poisoning is Neostigmine Atropine sulphate Phentolamine Trimethaphan 122. Motif is represented by:- Commas repeated on the lattice 3D translational periodic arrangement of points Geometric shapes of lattice Centre of symmetry in lattice 123. LOSARTAN is Angiotensin II receptor antagonist Potent anti- hypotensive agent Calcium channel blocker Atrial fibrillating agent 124. An antitubercular drug that is a pyridine derivative is, Ethambutol Ethionamide Pyrazinamide Para-aminosalicylic acid 125. The phylum chordata is characterised by the presence of Spinal cord Notochord Nerve chord None of these