GRANULATION TISSUE.pptx

Healing by granulation tissue

1. GRANULATION TISSUE

2. Process of repair begins early – 24 hours It begins as a proliferation of young connective tissue cells (fibroblast) and proliferation of new blood vessels – 3 to 7 days. Two types of granulation tissue present based on duration of repair: Early ( Vascular) and Late

3. MICROSCOPIC FEATURES: Surface necrotic layer of fibrin showing degenerated leukocytes and RBC Intermediate layer : hair pin bend like vascular loops Deeper layer : Proliferating Fibroblast More deeper : Plasma cells Infiltration by neutrophils , macrophages and lymphocytes. Lastly , deepest being the normal tissue.

4. VIVA QUESTIONS: 1. INTERMEDIATE LAYER Vascular loops are perpendicular to the surface Fibroblast are parallel to the surface 2. DEEPER LAYERS : Fibroblast are parallel to the vessels. 3. STILL DEEPER LAYERS: Fibroblast are at right angle to the vessels 4. Granulation tissue matures from below upwards.