Gullian Barrie Syndrome , Ascending Paralysis.pptx

Its a CNS disorder related to GIT , only CNS disorder

1. Guillain-Barré syndrome A presentation by : MAHARSHI AKHANI(19097)

2. Auto immune progressive Neurological disease (Fast onset) → Type 4 HSR Only Neurological disease as/w GIT

3. Etiology High Risk with : Covid19 Zika virus EBV/CMV SLE Rabies Neural derived Vaccine Acute Dysentery (campylobacter jejunii)

4. Pathology

5. Subtypes of GBS: Acute inflammatory demyelinating (AIDP) poly neuropathy Acute motor axonal neuropathy (AMAN) Acute motor sensory axonal neuropathy (AMSAN) Miller Fischer syndrome(Axonal+ Demylination)

6. Clinical Features Ascending symmetrical Flaccid paralysis Flaccid Paraplegia Truncal paraplegia Quadriplegia (arm weakness) Respiratory muscle weakness/paralysis Mcc of death due to GBS Resp. Acidosis Type-2 Resp. Failure Neck Floppiness Facial N. palsy (LAST) [Facial Diplegia]

7. 7) Bulbar paralysis CN 9,10,12 cant talk Cant eat Cant drink

8. Sensory Involvement Might be present Paraesthesia Muscle pain

9. ANS involvement T1-T4 lesion = Bradycardia and HypoTn Leading to REFLEX VasoConstriction That will show High BP Therfore: will show WIDE fluctuating BP

10. INVESTIGATIONS CSF Exam : Albumin/cytological dissociation Nerve Conduction Study : increased LATENCY MRI - Spine : Demylination is seen Antibody detection: Anti-GM1 ( AIDP) Anti-GQ1 (MFS) Anti-GD1 (AMAN)

11. Treatment (DOC) IV-IG Plasmapheresis