Haematinics

pharmaceutical inorganic chemistry

1. HAEMATINICS

2. FERROUS SULPHATE INTRODUCTION Iron(II ) sulfate or ferrous sulfate denotes a range of salts with the formula FeSO ₄ ·7H ₂O. These compounds exist most commonly as the heptahydrate but are known for several values of x. The hydrated form is used medically to treat iron deficiency, and also for industrial applications.  These are the nutrients substances required for the formulation of blood cells and used in the treatment of anemia .

3. Formula :  FeSO 4 . 7H2O Molar mass :  278.02 Melting point :  70 °C Density :  2.84 g/cm³ Boiling point :  330 °C Soluble in :  Water People also search for :  Folate , Copper(II) sulfate , 

4. PREPARATION It is prepared by treating slight excess of iron filings with dilute sulphuric acid Fe + H 2 SO 4 = FeSO 4 + H 2 PROPERTIES It occurs as crystal as well as dry form Ferrous sulphate crystal occurs as bluish green crystals or crystalline powder. It consists of seven molecules of water of hydration. It is odourless and has a metallic astrigent taste. It is freely soluble in water and insoluble in alcohol.

5. CHEMICAL PROPERTIES It forms double salt with ammonium sulphate . FeSO 4 + NH 4 (SO 4 ) 2 = FeSO 4 NH 4 (SO 4 )6H 2 It’s a reducing agent , it decolorizes acidified potassium permanganate 2FeSO 4 + 2KMnO 4 + 4H 2 SO 4 K 2 SO 4 + 2MnSO 4 + Fe(SO 4 ) 2 + 4H 2 O It reduces mecuric chloride to mercurous chloride 2Fe 2 + 2HgCl 2 = Hg 2 Cl 2 + 2Fe 3 + 2Cl When exposed to moist air , it gets oxidized to ferric sulphate and when heated it gets decomposed to ferric oxide , sulphur dioxide and sulphuric acid. 2FeSO 4 7H 2 O = Fe 2 O 3 + SO 2 + H 2 SO 4 + 4H 2 O

6. IP STANDARD Not less than 98.0% and not more than 104.0% of FeSO4 7H2O ASSAY METHOD : 1 REDOX TITRATION – CERIOMETRY Dissolve an accurately weighted amount of substance in water , add sulphuric acid and titrate against 0.1M cerric ammonium sulphate using ferroinsulphate as indicator. The end point is disappearance of red colour . Ce 4+ + Fe 2+ = Ce 3+ + Fe 3+

7. METHOD : 1 REDOX TITRATION – CERIOMETRY Dissolve an accurately weighted amount of substance in sulphuric acid and titrate against 0.1M Potassium permanganate. Potassium permanganate act as self indicator and the end point is the appearance of permanent pale pink colour . 2FeSO 4 + 2KMnO 4 + 4H 2 SO 4 K 2 SO 4 + 2MnSO 4 + Fe(SO4 ) 2 + 4H 2 O USES It is used as haematinics in the treatment of iron deficiency anemia.

8. FERROUS GLUCONATE INTRODUCTION Iron(II ) gluconate , or ferrous gluconate , is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. It is marketed under brand names such as Fergon , Ferralet and Simron .

9. Formula :   C 12 H 24 FeO 14 Molar mass :   448.156 g/mol ChemSpider ID :   19953133 Appearance :   light yellow to brown powder PubChem CID :   9291 IUPAC ID :   (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid, iron People also search for :   Iron(II) sulfate ,   Folate ,  Iron(II) fumarate , PREPARATION Gluconic acid react with ferrous carbonate gives ferrous gluconate . Further , it is crystallized with two molecule of water of hydration 2C 6 H 12 7 + FeCO 3 + H 2 O = Fe(C 6 H 11 7 ) 2 2H 2 O + CO 2

10. PROPERTIES It occurs as yellowish grey or pale greenish yellow granules or powder It has slight odour of burnt sugar Slightly soluble in cold water and more soluble in hot water Its aqueous solution is acidic in nature Its affected by light IP LIMIT Not less than 95.0 % and not more than 102.0 %

11. ASSAY REDOX TITRATION Dissolve an accurately weighted amount of substance in dilute sulphuric acid and add sodium bicarbonate ( to produce CO2 , which prevents oxidation of ferrous to ferric state. ) add ferroin as indicator and titrate with 0.1M cerric ammonium nitrate. The end point is disappearance of red colour Ce 4+ + Fe 2+ = Ce 3+ + Fe 3 + USES It is used as hematinic in the prevention and treatment of iron deficiency anemia

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