Haematinics

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1. Welcome To My presentation

2. Name: MD. Zahirul Islam Roll:333 Batch:12 th Department of pharmacy World University of Bangladesh

3. Presentation of Haematinics

4. Haematinics :  General term for those nutrients, including iron, folic acid, and vitamin B  12 , required for the formation and development of blood cells in bone marrow (the process of haematopoiesis ), deficiency of which may result in anaemia

5. Main Haematinics are: 1.Iron 2.Vit-B12 3. Folic acid

6. Iron As Haematinic Agent Hematopoiesis The production of circulating erythrocytes, leukocytes and platelets from undifferentiated stem cells, is called hematopoiesis . It requires: Iron –for Hb formation

7. Anemia: Decreased capacity of RBCs to carry oxygen to tissues. Causes: Blood loss Impaired RBC functions, due to deficiency of

8. Iron deficiency occurs Iron deficiency occurs due to: Malnutrition Loss Congenital atransferrinemia (inability to release iron from transferrin )

9. Iron storage Iron is the integral component of haeme . In our body: 66-67% of iron is present in hemoglobin. 3% occurs in myoglobin 1% in enzymes - cytochrome , catalase , peroxidase 25% is stored in form of ferritin and hemosiderin

10. Source of Iron Heme iron (present in meat) Inorganic iron Free inorganic iron is very toxic, thus there are regulatory mechanisms for: a. Absorption b. Transport c. Storage of iron

11. Factors facilitating Iron Absorption Acid Acid enhances dissolution and reduction of ferric iron. Reducing Substances Ascorbic acid reduces ferric iron and forms absorbable complexes Meat Meat also facilitates iron absorption by increasing HCl secretion Pregnancy/ Menstruation Due to increased iron requirement

12. Vitamin B12 A vitamin important for the normal formation of red blood cells and the health of the nerve tissues. Undetected and untreated vitamin B12 deficiency can lead to anemia and permanent nerve and brain damage.

13. Causes of vit B12 deficiency 1.Decrease intake in diet 2. Increase demand during growing peroid pregnancy 3. Fish tape worm infestation

14. Vit B12 deficiency desease 1.Megaloblastic anemia 2. Crohn's disease 3.celiac disease

15. Folic acid A yellow crystalline water-soluble vitamin essential for cell growth and reproduction. It functions as a coenzyme with vitamins B 12  in the metabolism and use of proteins and in the formation of nucleic acids and  heme  for hemoglobin

16. Indication of folic acid 1.To treat megaloblastic anemia due to folate deficiency 2. Liver desease 3.Chronic disease 4. Renal dialysis 5. pregnancy

17. Thanks to All