Headache in Multiple Sclerosis.pptx

Headache in Multiple Sclerosis

1. Headache in multiple sclerosis Ade Wijaya , MD – October 2022

2. Introduction Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology which is characterized by relapses and predominantly affects women in the second or the third decade of life MS relapses may occur with visual disturbances, motor and sensory involvement, or cerebellar or spinal involvement. Initial and relapse symptoms of MS may include acute brachial pain, sore throat, hypoglossal nerve palsy, epileptic seizures, and headache Gökhan , Ö. Z. E. R., Ergün , U., & İnan , L. E. (2018). Headache in Multiple Sclerosis from A Different Perspective: A Prospective Study.  Journal of Clinical and Experimental Investigations ,  9 (1), 9-13.

3. Headache in MS Overall prevalence: 55.6-68 % Migraine-like headache: 14-16.7 % Tension type headache: 16-31.9 % Cluster headache: 0.8 % Primary stabbing headache: 11-18 % Mixed type headache: 13-22 % Unclassified headache: 8.6 % Gökhan , Ö. Z. E. R., Ergün , U., & İnan , L. E. (2018). Headache in Multiple Sclerosis from A Different Perspective: A Prospective Study.  Journal of Clinical and Experimental Investigations ,  9 (1), 9-13.

4. Headache in MS 13 % as presenting symptoms Pulse steroid therapy for 3 to 5 days Headache symptoms improved partially or completely in 3 to 10 days Gökhan , Ö. Z. E. R., Ergün , U., & İnan , L. E. (2018). Headache in Multiple Sclerosis from A Different Perspective: A Prospective Study.  Journal of Clinical and Experimental Investigations ,  9 (1), 9-13.

5. Pathophysiology Increased cytokine synthesis and specifically IL-10, an anti-inflammatory cytokine Gökhan , Ö. Z. E. R., Ergün , U., & İnan , L. E. (2018). Headache in Multiple Sclerosis from A Different Perspective: A Prospective Study.  Journal of Clinical and Experimental Investigations ,  9 (1), 9-13. Munno I, Marinaro M, Bassi A et al. Immunological aspects in migraine: increase of IL-10 plasma levels during attack. Headache. 2001;41:764–7 Beebe AM, Cua DJ, de Waal Malefyt R The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Cytokine Growth Factor Rev. 2002;13:403–12.

6. Summary Headache is common in MS patients Can be as presenting or relaps symptoms Treatment: steroids and other analgesics

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