Hematinics ,function of iron and vitamin b12

Presentation

1. HEMATINICS Afra Ali 19

2. INTRODUCTION TO HEMATINICS Miscellanous/Adjuvant hematinics Copper Pyridoxine

3. Brief Overview of Erythropoesis Brief Overview of Erythropoesis

4. PHYSIOLOGICAL FUNCTIONS OF IRON Blood production: Hemoglobin Energy production : myoglobin Enzymes DNA and amino acid synthesis Immune function: Nutritional immunity ferroptosis(fenton reaction) CMI Other functions :muscles, bone marrow, and organ function synthesis of collagen and some neurotransmitters

5. PHYSIOLOGICAL FUNCTIONS OFVITAMIN B12 normal functioning of the brain and nervous system cognitive functioning (ability to think) formation of red blood cells and anemia prevention helping create and regulate DNA possibly preventing congenital abnormalities helping protect the eyes from macular degeneration necessary for energy production].

6. Erythropoetin Uses: Chronic Kidney Disease (CKD) Anemia (in Premature Infants,Cancer-Associated, HIV-Associated) Preoperative Use ADR • Common: • Hypertension (most common)-Headache and fatigue • Injection site reactions • Serious: • Thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism) • Increased risk of tumor progression in some cancers • Pure red cell aplasia (rare)

7. MCQ Which of the following regulates the secretion of erythropoietin hormone? (a) Oxygen (b) Proteins (c) Number of Red Blood Cells (d) The concentration of haemoglobin

8. MCQ 2. Vitamin B2 is involved in myelin synthesis through which of the following enzymes? (a) methionine synthase (b) methyl malonyl coA mutase (c) Folate reductase (d) heme oxygenase