Hemostasis : Blood clotting

process and factors involve in blood clotting, factors in blood clotting

1. Hemostasis Dr Alok Tripathi Department of Biotechnology

2. Main processes of hemostasis 23-12-2007 3

3. Hemostasis http://cwx.prenhall.com/bookbind/pubbooks/silverthorn2 23-12-2007 4

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5. Adhesion of platelets, white thrombus http://cwx.prenhall.com/bookbind/pubbooks/silverthorn2 23-12-2007 6

6. Thrombocytes 23-12-2007 7

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8. Platelets in “normal” state 23-12-2007 9

9. The activated platelets 23-12-2007 10

10. Thrombin and collagen are the two most important platelet activators. ADP is considered a weak agonist; it causes aggregation but not granule release. (GP, glycoprotein; R1–R5 , various receptors; AC, adenylyl cyclase ; PLA2, phospholipase A2; PL, phospholipids; PLC β, phospholipase C β; PIP2, phosphatidylinositol 4,5-bisphosphate; cAMP , cyclic AMP; PKC , protein kinase C; TxA2, thromboxane A2; IP3, inositol 1,4,5-trisphosphate; DAG, 1,2-diacylglycerol. The G proteins that are involved are not shown .

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16. Conversion of prothrombin to thrombin 23-12-2007 18

17. Fibrinogen 23-12-2007 19

18. Conversion of fibrin from fibrinogen 23-12-2007 20 2nA+2nB n(A  ) 2 (B )­ 2  2  n  2  2  2  (  2  2 2 2 ) n Fibrin Monomer Fibrin Clot

19. Fibrinogen structure 23-12-2007 21

20. Fibrin network 23-12-2007 22

21. Initiation of coagulation 23-12-2007 23

22. Regulation of coagulation 23-12-2007 24

23. Serine protease inhibitors 23-12-2007 25

24. Protein C system 23-12-2007 26

25. Fibrinolysis 23-12-2007 27

26. Endothelium and coagulation 23-12-2007 29

27. Blood cells and coagulation 23-12-2007 30

28. Disturbances of blood coagulation 23-12-2007 31

29. Hypocoagulation 23-12-2007 32

30. Blood coagulation and blood cells 23-12-2007 33

31. Endothelium and blood clotting 23-12-2007 34 A good overview and illustrations: http://ntri.tamuk.edu/homepage-ntri/lectures/clotting.html