Hemostasis: Mechanism and causes of its dysregulation.pptx

Platelets have many functions, including phagocytosis of viruses, latex, immune complexes and iron; maintenance of vascular integrity
by filling gaps that form in the endothelium and by directly supporting endothelial cells; synthesis and release of vWF in humans and some animal species, and fibronectin;
participating in surface adhesion andactivation processess (Caen and Rosa, 1995; Clemetson, 1995; Nurden, 1995);
production and release of potent smooth muscle and endothelial cell proliferating factor( s); and retraction of clots, a process that stabilizes the initial hemostatic plug and activates clot lysis.

1. Hemostasis By Romissaa Aly Esmail Assistant lecturer of Oral Medicine, Periodontology, Diagnosis and Dental Radiology (Al-Azhar University)

2. Contents Introduction Models of Hemostasis Mechanisms by which inflammation induces disturbance of the hemostatic system Platelet Activation by Cancer Cells Pathological hemostasis Stress and Hemostasis Influence of antidepressants on hemostasis Hemostasis and aging

3. Fig. 3. APC activated protein C; AT antithrombin; GAG glycosaminoglycans with antithrombin inhibit excess thrombin; PC protein C; S protein S, the cofactor of protein C; T thrombin; TF tissue factor; TM thrombomodulin. Va and VIIIa with slashes indicate Va and VIIIa inactivated by activated protein C. Activated platelets and fibrin form a hemostatic plug.

4. Fibrinolysis

5. Models of Hemostasis

6. Inflammation and haemostasis

7. Mechanisms by which inflammation induces disturbance of the hemostatic system

8. Hemostasis and Malignancy

9. Histological Evidence That Hemostasis Plays a Role in Tumor Biology

10. Platelet Activation by Cancer Cells

11. Pathological hemostasis

12. Disorders of primary hemostasis Both constitutive and acquired defects of primary hemostasis preferentially induce sc or mucosal bleeding, appearing spontaneously or after minimal trauma. Platelet and vWF abnormalities are the most frequent.

13. Stress and Hemostasis

14. Influence of antidepressants on hemostasis

15. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), are widely used for the treatment of depression and anxious disorders.

16. Hemostasis and aging

17. R eferences 1.Roberts HR, Monroe DM, Escobar MA, Weiskopf RB. Current concepts of hemostasis : implications for therapy. The Journal of the American Society of Anesthesiologists. 2004 Mar 1;100(3):722-30. 2.Dodds WJ. Hemostasis . InClinical biochemistry of domestic animals 1997 Jan 1 (pp. 241-283). Academic Press. 3. Franchini M. Hemostasis and aging. Critical reviews in oncology/hematology. 2006 Nov 1;60(2):144-51. 4. Francis JL, Biggerstaff J, Amirkhosravi A. Hemostasis and malignancy. InSeminars in thrombosis and hemostasis 1998 Apr (Vol. 24, No. 02, pp. 93-109). Copyright© 1998 by Thieme Medical Publishers, Inc.. 5. Lasne D, Jude B, Susen S. From normal to pathological hemostasis . Canadian journal of anaesthesia = Journal canadien d'anesthesie . 2006 Jun 1;53(6 Suppl ):S2-11. 6.Margetic S. Inflammation and hemostasis . Biochemia medica . 2012 Feb 15;22(1):49-62.

18. 7. McMichael M. New models of hemostasis. Topics in companion animal medicine. 2012 May 1;27(2):40-5. 8. Versteeg HH, Heemskerk JW, Levi M, Reitsma PH. New fundamentals in hemostasis . Physiological reviews. 2013 Jan;93(1):327-58. 9. Austin AW, Wissmann T, von Kanel R. Stress and hemostasis : an update. InSeminars in thrombosis and hemostasis 2013 Nov (Vol. 39, No. 08, pp. 902-912). Thieme Medical Publishers. 10. Troy GC. An overview of hemostasis . Veterinary Clinics of North America: Small Animal Practice. 1988 Jan 1;18(1):5-20. 11,Halperin D, Reber G. Influence of antidepressants on hemostasis . Dialogues in clinical neuroscience. 2022 Apr 1.