hepatits pharmacotherapeutics and management

hepatitis pharmacology and therapeutics

1. Hepatitis ( Pathophysiology ) Pawan Maharjan

2. Introduction Hepatitis means inflammation of the liver that might be due to Genetic diseases, infectious organism, toxins , or therapeutic agents (medicine). Hepatitis can heal on its own with no significant consequence, or it can progress to scarring of the liver.

3. Etiology Drugs (Paracetamol, methotrexate, isoniazid) Alcohol Genetic disease/autoimmune Hepatitis virus HAV, HBV, HCV, HDV, HEV

4. Clinical Features Jaundice Dark Urine Anorexia Abdominal distention Low grade fever Nausea/ vomitting

5. Pathophysiology

6. Diagnosis Liver function test Blood testing for antibody of viruses. Blood count.

7. Complication Liver cirrhosis Advance liver disease( GI bleeding, poor blood clotting, fluid in abdomen etc ) Hepatocellular carcinoma

8. Treatment Goal To remove all the offending factors. To slow or stop damage of liver cells To decrease other symptoms .

9. Management Non pharmacological Avoid alcohol Avoid medicine and toxin causing hepatitis Safe hygiene Surgical : Liver transplantation

10. Management cont. Pharmacological Anti hepatitis virus drug(Lamivudine, adefovir , for HBV, and interferon , ribavirin for HBC) Side effect : Ribavirin might cause birth defect so avoid in pregnancy. Interferon have following common side effects Flu like symptom: headache, fever, chill, fatigue etc Psychiatric symptom: depression, irritable, difficulty in sleeping etc.

11. Prevention Limit uses of alcohol Do not use hepatotoxic medicine unnecessarily Vaccination against hepatitis viruses. Use only sterile needle for injection.

12. Thank you