Hetrocyclic compound Pyrazole

Five membered heterocyclic compound with two hetero atom. two nitrogen atom adjacent to each other in a ring structure

1. Hetrocyclic compound - Pyrazole Lecture by S.Mathivanan .,M.Pharm Asst professor Pharmacy

2. Pyrazole Pyrazole is the name given by “LUDWIG KNORR” to this class of compounds in 1883. The simple doubly unsaturated compound containing two nitrogen and three carbon atoms in the ring, with the nitrogen atoms neighboring, is known as pyrazole .

3. History For a long time no pyrazole derivative had been found in nature, but in 1959 β-(1- pyrazolyl ) alanine was isolated from the seeds of water melons ( Citurllus lanatus ) (L. Fowden ).

4. 3-n-nonylpyrazole is the first natural pyrazole thta has been obtained from a plant Houttuynia cordata which belongs to the family Piperaceae . This compounds exhibit anti-microbial property

5. Analogues of Pyrazole Pyrazole Pyrazoline Pyrazolidine 5-Pyrazolinone 3,5-Pyrazolidinedione Imidazole (will discuss later)

6. Physical properties Crystalline solid Pyridine like odour Bitter taste Melting point 70°C Boiling point 187°C Soluble in water and organic solvents.

7. Chemical properties

8. Synthesis of Pyrazole

9. Reactions of Pyrazole

10. Medicinal uses of Pyrazole

11. Sulfaphenazole : Sulphonamide antibiotic. Used for treating cough and allergy Celecoxib : NSAID . Used to treat arthritis , pain, menstrual cramps, and colonic polyps.

12. Thank you..!!!