Histological Structure of The Renal Corpuscle Suits its function- maha hammady.pptx

Renal corpuscle is the major part of the uriniferous tubules; the functional unit of our kidneys. It can be affected by a variety of congenital, infectious, iatrogenic, and malignant diseases. Studying the normal structure of the human renal corpuscle is fundamental to nephrologist, radiologist, and pathologists. Moreover, understanding the normal structure of the renal corpuscle is a fundamental aspect in preclinical and clinical research. In this presentation, we have provided a detailed microscopic description of the renal corpuscle and its related structures in relation to their function. Lastly, we have linked many molecular structures to known renal conditions.

1. Histological Structure of The Renal Corpuscle Suits its function Maha Hammady Assistant Lecturer of Medical Histology & Cell Biology, Faculty of Medicine Alexandria University

2. Bibliography Pawlina W, Ross MH. Histology: A text and atlas, international edition: With correlated cell and molecular biology: Wolters Kluwer Law & Business; 2019 Mescher A. Junqueira’s basic histology text and atlas. 15th ed. new york : McGraw-Hill Education; 2018 Gartner L. Cell biology and histology. 8th ed. New York: Wolters Kluwer; 2019 Farquhar MG. The glomerular basement membrane: Not gone, just forgotten. J Clin Invest. 2006;116(8):2090-3. Andrews PM, Porter KR. A scanning electron microscopic study of the nephron. Am J Anat. 1974;140(1):81-115. Fujita T, Tokunaga J, Edanaga M. Scanning electron microscopy of the glomerular filtration membrane in the rat kidney. Cell Tissue Res. 1976;166(3):299-314. Shirato I, Tomino Y, Koide H, Sakai T. Fine structure of the glomerular basement membrane of the rat kidney visualized by high-resolution scanning electron microscopy. Cell Tissue Res. 1991;266(1):1-10. Andrews PM. Scanning electron microscopy of the nephrotic kidney. Virchows Arch B Cell Pathol . 1975;17(3):195-211. Bulger RE, Siegel FL, Pendergrass R. Scanning and transmission electron microscopy of the rat kidney. Am J Anat. 1974;139(4):483-501. Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, et al. Three-dimensional architecture of glomerular endothelial cells revealed by fib- sem tomography. Front Cell Dev Biol. 2021;9:653472. Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, et al. Three-dimensional architecture of glomerular endothelial cells revealed by fib- sem tomography. Front Cell Dev Biol. 2021;9:653472. Spinelli F. Structure and development of the renal glomerulus as revealed by scanning electron microscopy. In: Bourne GH, Danielli JF, Jeon KW, editors. International review of cytology: Academic Press; 1974. p. 345-81. Tokunaga J, Edanaga M, Fujita T, Adachi K. Freeze cracking of scanning electron microscope specimens. A study of the kidney and spleen. Arch Histol Jpn . 1974;37(2):165-82. Webber WA, Lee J. The ciliary pattern of the parietal layer of bowman's capsule. Anat Rec. 1974;180(3):449-55.

3. The Uriniferous tubule Nephron Collecting tubules Urine production Modify the concentration of the secretory product

4. The Nephron Renal Corpuscle Tubular system Filtering part Resorption and secretion

5. The Renal Corpuscle

6. 1-Bowman capsule

7. 1-Bowman capsule

8. 1-Bowman capsule

9. 1-Bowman capsule

10. Podocytes

11. podocyte podocyte Podocytes

12. podocyte Podocytes

13. Podocytes

14. 2-Glomerulus afferent Efferent Afferent

15. 2-Glomerulus

16. 3-Mesangium

17. 3-Mesangium

18. Glomerular filtration barrier

19. 1-Specialized fenestrated endothelial cells with well-developed glycocalyx

20. 1-Specialized fenestrated endothelial cells with well-developed glycocalyx

21. 2-Unique GBM

22. 2-Unique GBM Lamina rara externa Lamina rara interna Lamina densa Albort ’ Syndrome Goodpasture syndrome & post-transplantation diseases.

23. 3-Slit diaphragm formed between the interdigitating secondary process of podocytes: 30 nm Congenital Nephrotic Syndrome

24. Bibliography Pawlina W, Ross MH. Histology: A text and atlas, international edition: With correlated cell and molecular biology: Wolters Kluwer Law & Business; 2019 Mescher A. Junqueira’s basic histology text and atlas. 15th ed. new york : McGraw-Hill Education; 2018 Gartner L. Cell biology and histology. 8th ed. New York: Wolters Kluwer; 2019 Farquhar MG. The glomerular basement membrane: Not gone, just forgotten. J Clin Invest. 2006;116(8):2090-3. Andrews PM, Porter KR. A scanning electron microscopic study of the nephron. Am J Anat. 1974;140(1):81-115. Fujita T, Tokunaga J, Edanaga M. Scanning electron microscopy of the glomerular filtration membrane in the rat kidney. Cell Tissue Res. 1976;166(3):299-314. Shirato I, Tomino Y, Koide H, Sakai T. Fine structure of the glomerular basement membrane of the rat kidney visualized by high-resolution scanning electron microscopy. Cell Tissue Res. 1991;266(1):1-10. Andrews PM. Scanning electron microscopy of the nephrotic kidney. Virchows Arch B Cell Pathol . 1975;17(3):195-211. Bulger RE, Siegel FL, Pendergrass R. Scanning and transmission electron microscopy of the rat kidney. Am J Anat. 1974;139(4):483-501. Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, et al. Three-dimensional architecture of glomerular endothelial cells revealed by fib- sem tomography. Front Cell Dev Biol. 2021;9:653472. Kawasaki Y, Hosoyamada Y, Miyaki T, Yamaguchi J, Kakuta S, Sakai T, et al. Three-dimensional architecture of glomerular endothelial cells revealed by fib- sem tomography. Front Cell Dev Biol. 2021;9:653472. Spinelli F. Structure and development of the renal glomerulus as revealed by scanning electron microscopy. In: Bourne GH, Danielli JF, Jeon KW, editors. International review of cytology: Academic Press; 1974. p. 345-81. Tokunaga J, Edanaga M, Fujita T, Adachi K. Freeze cracking of scanning electron microscope specimens. A study of the kidney and spleen. Arch Histol Jpn . 1974;37(2):165-82. Webber WA, Lee J. The ciliary pattern of the parietal layer of bowman's capsule. Anat Rec. 1974;180(3):449-55.

25. Thank you