Histology of male reproductive system

very well describes the different male reproductive tracts on histology aspects and their importance.

1. Histology of Male Reproductive
System
Dr. Laxman Khanal
Asst. Professor (Department of Anatomy)
BPKIHS, Nepal
To MBBS 2
nd
year
09-12-2016

2. Q. Crystelof Reinkeis the characteristic feature of-
a.Cell of Leydig b. Sertolicell
c. Spermatogonia d. spermatozoa
Q. Most numerous cell organellin Leydigcell is-
a.SER b. RER
c. Ribosome d. Lysosome
Q. Most of the duct system of male reproductive system is
lined by ----------type of epithelium.
a.Simple columnerb. pseudostratified ciliated columner
c. Simple cuboidald. stratified columner

3. Anatomical subdivision of male reproductive system
Male gonad (Testis)
Duct system (efferent ductules, Epididymis, vas
deferens, ejaculatory duct and part of urethra)
Accessory glands-seminal vesicle, prostate and
bulbourethral gland (Cowper’s gland)
Penis
Functionofmalereproductivesystem
Production,storage,nourishmentandtransmission
ofmalegametes(spermatozoa)
Productionofmalehormones

5. Developmental site-post abdominal wall
Mature position-cooler scrotum (by descent of testis)
Histology of testis
No of lobule-200-300
Each lobule –1-3 ST
Covering of the testis
1.T vaginalis
2.T albuginea
3.T vasculosa

6. Seminiferoustubules
Cell inside the tubules-spermatogenic cell and Sertolicell
Cell between the tubules-interstitial cell of Leydig
•Fromperipheryto
centerarrangementof
thecellsisimmature
tomaturecells
•Lumenofthetubule
containsmostmature
seriesof cell
(spermatozoa)

7. Blood testis barrier
Spacebetweensertolicells
Basalcompartment
Luminalcompartment

8. FunctionofTestis
FunctionsofLeydigcell
•SensesLHandsecretsandrogen(testosterone)
responsibleformaletypeofsexualcharacters
FunctionofSertolicell
•Nourishmentofspermatogeniccells
•Bloodtestisbarrier
•Phagocytosisofresidualbodies
•SensesFSHandsecretsABP
•InfetussecretsMIS(suppressesthefemalegenitaltract
development)
Spermatogeniccells-actasmalegametes

9. Castor Semenya–800 m gold
medalist in Rio Olympic 2016.
She was Found to have
suffered from androgen
insensitivity syndrome (AIS).
•Genotype: 44+XY
•Phenotype: Female
•Y chromosome present
•Leydig’scells present
•Normal androgen level
•No receptor found for
androgen
•no male sex organ develops
•Looks like female

10. •Seminiferoustubules
•Straighttubules
•Retetestis
•Efferentductules(15-20)
•DuctofEpididymis
•Vasdeferens

11. •Theepididymisisalong&extremelyconvolutedduct
lyingontheposterioraspectofthetestis.
•Madeupofhead(efferentductules),body&tail(duct
ofEpididymis).
•Amountofsmoothmuscleincreasesfromheadtotail
direction.
•Liningepithelium-pseudostratifiedcolumner
epitheliumwithstereocillia.
•Function-storageandmaturationofspermatozoa.
Epididymis

13. Appreciatethesinglelayerofsmoothmusclewhichwill
increaseasitisfolloweddistally.
Lining–pseudostratifiedcolumnarwithstereocilia

14. No muscle layer
Uniform shape of tubules
Stereociliaabsent
Muscle layer present
Variable shape of ducts
Stereociliapresent

15. Vas Deferens
•Length-45cm
•Continuefromtailofepididymistothe
seminalvesicle
•Liningepth-pseudostratifiedcolumner
epitheliumwithfewstereocilia.
•Multiplelayerofsmoothmuscle(outerand
innerlayeroflongitudinalmusclewithcircular
layerinbetween)

16. Liningepithelium
Threelayerofsmoothmuscle
L
c
L
Theepithelialliningand
laminapropriaarethrown
intolongitudinalfolds,
permittingexpansionofthe
ductduringejaculation.

17. •Thedilateddistalportionofeachductusdeferens,
knownastheampulla,receivesashortductdrainingthe
seminalvesicle,thusformingtheshortejaculatoryduct.
•Theejaculatoryductsfromeachsideconvergetojoin
theurethraasitpassesthroughtheprostategland.

18. Seminal vesicle
•Secrets 70% of seminal fluid
which is alkaline
•Secretion is rich in fructose,
vitamin C and prostaglandins
•Lining epth-pseudostratified
columner
•Lumen is highly irregular and
recessed giving a honeycombed
appearance

19. Honeycomb appearance –lumen of seminal vesicle

20. Prostate gland
•Surroundsthebladderneckandthepartof
theurethra,knownastheprostaticurethra.
•Inthesubstanceofthegland,theurethra
mergeswiththeejaculatoryducts.
•Histologicallytheprostateiscompound
tubulo-alveolarglandsembeddedina
fibromuscularstroma.
•Secretionconsistsof30%ofseminalfluid.

21. Inthehistologicalsectionprostatehasarrangementof
glandsinthreeconcentriclayers.
1.Innerzone-mucosalgland
2.Centralzone-submucosalgland
3.Peripheralzone-maingland
•Allthesecretionfinallysecretedintoprostaticurethra.
Peripheral zone = prone for carcinoma (PSA)
Inner zone= prone for BPH
Inner zone
Central zone
Peripheral zone

22. •Prostate
= glandular tissue + fibromuscular stroma.
•Contains prostatic urethra
•Glandsarelinebysimpleorpseudostratifiedcolumner
epithelium.
•Secretionisrichinglycoprotein.Sometimelumenof
glandcontainsdepositionofglycoproteinascorpora
amylaceaorprostaticconcretion.

23. Benign prostate hyperplasia
Testosterone Dihydrotestosterone(DHT)
5
α
reductase

24. •Found in urogenital diaphragm
•Secret preseminalmucus secretion
•Help to lubricate the penile urethra

25. Penis
•Themaincomponentsofthepenisarethree
cylindricalmassesoferectiletissue,plusthe
urethra,surroundedbyskin.
•Atitsdistalend,thecorpusspongiosum
expandstoformtheglanspenis.
•Exceptfortheprostaticpartofurethra,and
mostdistalpartofurethraliningis
pseudostratifiedcolumnerepithlium.

27. •Corpora cavernosa
•Corpus spongiosum •Tunica albuginea
•Deep fascia of penis
•Superficial fascia

28. Sexual stimulation
Parasympathetic
Stimulation (S2-S4)
Increased blood flow.
Smooth muscle relaxation.
Erection
Reflex sympathetic
stimulation (L1)
Emission
Blood flow decreases.
Smooth muscle contracts
Contraction of BS & IC
Ejaculation