Histopathology slide of

histopathology slides

1. Histopathology slide of – Typhoid Ulcer ilem Tuberculous Lymphadenitis Amoebic colitis Dr. Sandeep singh GMC

2. Typhoid Ulcer Acute infection caused by Salmonella typhi . Ingested through contaminated food and water. Characteristic – Rise in temperature , rose spots on skin.

3. Grossly Ileum is affected most often Peyer’s Patches show oval typhoid ulcer with their long axis along with length of the bowel. Base of the ulcer is black due to sloughed mucosa , margin is raised and cellular proliferation.

4. Microcopically Hyperaemia , oedema and cellular proliferation consisting of phagocytic histiocytes , lymphocytes and plasma cells

5. Tuberculous lymphadenitis The most common form of tuberculosis infections that appears outside the lung It is always secondary G/A The lymph nodes are enlarged and are matted together due to periadenitis . The cut surface in the tuberculous areas is yellow, cheesy, opaque and caseous while elsewhere is grey brown

6. Caseating granulomatous lymphadenitis. A , Cut section of matted mass of lymph nodes shows merging capsules and large areas of caseation necrosis (arrow)

7. M/E The caseous areas show nuclear debris The periphery of caseous foci shows granulomatous inflammation consisting of epithelioid cells, surrounded by lymphocytes and some plasma cells. Epithelioid cells may fuse to form giant cells in the granuloma and may have nuclear arrangement at the periphery of the cell ( Langhans ’ giant cell) or the nuclei may be distributed haphazardly (foreign body giant cell)

8. Caseating epithelioid cell granulomas with some Langhans ’ giant cells in the cortex of lymph node.

9. Tuberculous lymphadenitis. Characteristic sliper -shaped epithelioid cells, minute caseation necrosis and Langhans ’ giant cells.

10. Tuberculous lymphadenitis. Large areas of caseation necrosis with dystrophic calcification, surrounded by epithelioid cells. Inbox shows AFB .

11. Amoebic colitis DUE to Entamoeba histolytica affect large intestine – Flask shaped ulcer Gross- amebic colitis. Several nodular lesions, slightly elevated areas of the mucosa with irregular necrotic centers in advance cases flask shapped ulcer narrow neck and broad base.

12. Microscopically Ulcerated area showing chronic inflammatory reaction consisting of lymphocytes , plasma cells, macrophages and eosinophils . Trophozoites of entamoeba are seen in inflammatory exudate with oedema and vascular congestion.