TCF7L2 Case Study
Discussion
TCF7L2 has been shown to be associated with T2MD in multiple ethnic groups. In the past two years
common single nucleotide polymorphism (SNP), rs7903146, located in intron 3 of the TCF7L2, has
been shown to be one of the most convincing susceptibility variants for T2DM. In the present report,
we examined the association betweenrs7903146 of the TCF7L2and serum leptin and ghrelin level, in
control and T2D subjects.
It is important to consider that TCF7L2 is expressed in different tissues, having important roles in
glucose metabolism such as gut, brain, liver, skeletal muscle, fat, and bones )24(.
The recent researches also have shown that leptin and ghrelin plays an important role in maintaining
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In the current study, there is a significant negative correlation between leptin and ghrelin, , meaning
when one increases, the other decreases.
Some other studies also have shown a negative correlation between leptin and ghrelin levels in the
body (37,38).
In our study population, there is a significant association between the T allele of the rs7903146 and
T2D. The odds ratio of T allele in the present study was (CI 95%; 0.26 (0.12,0.57), 1.36, p=0.26).
The OR obtained in this study is higher than almost all other ORs in the previous studies in other
populations, showing the importance of this SNP in Iranian population.
In our study, the frequency of TT genotype of the SNP examined was significantly higher in T2D
subjects, compared to the control subjects (50.6 vs. 15.6%, respectively; p 0.001), while the CC and
CT genotype frequency of SNP, rs7903146 were higher in control than patient subjects. The risk for
T2D was significantly higher for the TT genotype, compared with the CC genotype, resulted in odds
ratio of (95% CI: 0.12(0.42,0.32), 2.15, p 0.001)
In line with our allele frequency results, Amoli et al. (39) also reported Allele and genotype
frequencies were significantly different between patients and controls TT vs. CT + CC [p 0.0081 OR
3.4 95%CI (1.27 11.9)] and T vs. C allele [p0.02 OR 1.4 95%CI (1.03 1.9)].
Liu et al. (40) in a Meta analysis showed that the T allele of rs7903146 was significantly correlated
with
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