HMP Shunt.

HMP Shunt.

1. HMP SHUNT AND ITS SIGNIFICANCE NIDHI SHARMA

2. Introduction Hexose monophosphate pathway or HMP shunt is also called pentose phosphate pathway or phospho-gluconate pathway. This is an alternative pathway to glycolysis and TCA cycle for the oxidation of glucose. This  pathway   occurs in the oxidative and non-oxidative phases, each comprising a series of reactions. The enzymes of HMP shunt are located in the cytosol. The tissues such as liver, adipose tissue, adrenal gland, erythrocytes, testes and lactating mammary gland, are highly active in HMP shunt. H MP shunt is more acidic in nature, since it concerned with the biosynthesis of NADH & pentoses .

3. (6) (6C) (6C) (6C) (5C) (6) (6) (6)

4. Glucose-6-phosphate (2) (2) (1) (5C) (5C) (7C) (3C) (4C) (6C) (6C) (6C) (3C) (5C) (6C) (2+2 ) (2) (2) (2) (2) (5)

5. The overall reaction may be represented as- 6 Glucose-6-phosphate + 12 NADP+ + 6H2O 6CO2 + 12 NADPH + 12H+ + 5 Glucose-6- phosphate Energetics- 1 NADPH = 3 ATP 12 NADPH = 12 X 3 ATP = 36 ATP