Hodgkin lymphoma Kabul medical university.pptx

Hodgkin

1. Kabul medical university Ali abad teaching hospital department of internal medicine Hodgkin lymphoma Dr. Ashraf dashti

2. Hodgkin lymphoma are lymphoid neoplasms in which malignant reed Sternberg cells are seen in lymph node biopsy Painless lymphadenopathy Definition

3. 1: Classic HL:(90)% Nodular sclerosis Mixed cellularity Lymphocyte rich Lymphocyte depleted 2: Non classic HL(nodular lymphocyte predominant) Types:

4. Painless mass in neck Fever, weight loss, night sweats, pruritus Pain (alcohol ingestion) 60-80% neck 30% axillary 10% inguinal CLINIC:

5. Routine radiography of chest May be asymptomatic Cough, SOB, retrosternal chest pain Rarely pleural effusion, or pericardial effusion Mediastinal mass

6. Fever>38°c night sweets Weight loss>10% over the past 6 months 20% stage1,2 50% in advanced disease B symptoms

7. Reactive lymph node in infectious mononucleosis Cat-scratch disease Drug reaction(phenytoin) DDx

8. CBC ESR LFT, RFT HIV IMAGING BIOPSY Diagnosis

9. Chemotherapy First line regimen ABVD(doxorubicin, bleomycin, vinblastine, dacarbazine) TREATMENT

10. Related to: (stage, age, gender, hemoglobin, albumin, WBC count, lymphocyte count) Cure rate: 0-2( 75%) ≥3(55%) 90%survival of 10 years in 1a, 2a 50-60%survival of 10 years in stage 3, 4 Old age, bulky disease, lymphocyte deflation, mixed cellularity are poor prognostic factors Prognosis

11. CMDT 2023 HARRISONS MANUAL OF INTERNAL MEDICINE UptoDate References

12. THANK YOU