HPV and Cervical Carcinogenesis-10.8.24.pdf

Cervicak cancer and HPV

1. Cervical cancer
carcinogenesis
Rahul D Modi
Division of GYN Oncology
Sir Ganga Ram Hospital, New Delhi

2. ❖HPV Virus & Pathogenesis
❖Recent literature review on HPV from India

3. Harald zur Hausen M.D., D.Sc.

4. Source : The Noble Foundation

5. Human Papilloma Virus
❖Double stranded DNA virus
❖Epitheliotrophic
❖>200 subtypes
❖5 Genera : Alpha,Beta, Gamma,Mu,Nu
❖Alpha -responsible for cancers
❖Majority are specific for anogenital
epithelium

6. ❖Two risk types : High risk & Low risk
❖High risk : cancers / Low risk : warts
❖Low risk : 6, 11, 42, 43 & 44
❖High risk : 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73 & 82
❖Most infections : transient & asymptomatic
❖Upto 80% of sexually active women will be infected with HPV at some point
of their lives
❖Chronicity + Persistence = Cancer

7. HPV Genome
D’Abramo et al. ,Open Virology (2011)

8. ❖HPV -easily transmitted through sexual contact
❖Risk begins with first sexual activity
❖Acquired by skin to skin contact, full intercourse is not necessary
❖80-85% of sexually active women -infected at some point of time
❖Co-infection with more than one type is possible
❖Immunity against one type does not protect against other type

11. E6 & E7
Seyler et al. ,Trends in Microbiology (2018)
Jain et al., Pathogens (2023)

12. Roden et al.
Nature Reviews Cancer, March 2018
Innate Immunity to HPV

14. Song et al., Oncology letters (2015)

16. Source : IARC website

17. IndiaFact Sheet, IARC

18. 1439 participants
Overall prevalence : 37.3%
11 types of HPV genotypes
ASC-H : 73.8%
HSIL : 93.4%
NILM : 26 %
HPV 16 : 78.2%
HPV 18 : 8.9%

26. Pooled
Prevalence
85%

27. South : 88%
North : 73%
East : 99%
Central : 71%
West : 77%
All India : 85%

28. “Thank you…..…”