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7.1: Introduction
• Human skeleton is initially cartilages and fibrous membranes
• Hyaline cartilage is the most abundant cartilage
• By age 25 the skeleton is completely hardened
• 206 bones make up the adult skeleton (20% of body mass)
• 80 bones of the axial skeleton
• 126 bones of the appendicular skeleton
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7.2: Bone Structure
• Bones of the skeletal system vary greatly in size and
shape
• There is similarity in structure, development, and
function
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Microscopic Structure
• Mature bone cells are called osteocytes
• Osteocytes transport nutrients and wastes
• The extracellular matrix of bone is largely collagen and
inorganic salts
• Collagen gives bone resilience
• Inorganic salts make bone hard
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7.3: Bone Development
and Growth
• Parts of the skeletal system begin to develop during the
first few weeks of prenatal development
• Bones replace existing connective tissue in one of two
ways:
• As intramembranous bones
• As endochondral bones
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Intramembranous Bones
• Intramembranous Ossification
• These bones originate within sheetlike layers of
connective tissues
• They are the broad, flat bones
• Skull bones (except mandible)
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Endochondral Bones
• Endochondral Ossification
• Bones begin as hyaline cartilage
• Form models for future bones
• These are most bones of the skeleton
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Factors Affecting Bone
Development, Growth and Repair
• Deficiency of Vitamin A – retards bone development
• Deficiency of Vitamin C – results in fragile bones
• Deficiency of Vitamin D – rickets, osteomalacia
• Insufficient Growth Hormone – dwarfism
• Excessive Growth Hormone – gigantism, acromegaly
• Insufficient Thyroid Hormone – delays bone growth
• Sex Hormones – promote bone formation; stimulate ossification
of epiphyseal plates
• Physical Stress – stimulates bone growth
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7.1 Clinical Application
Fractures
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7.4: Bone Function
• Bones shape, support, and protect body structures
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Support, Protection,
and Movement
• Support, Movement & Protection
• Gives shape to head, etc.
• Supports body’s weight
• Protects lungs, etc.
• Bones and muscles interact
• When limbs or body parts move
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Blood Cell Formation
• Blood Cell Formation
• Also known as hematopoiesis
• Occurs in the red bone marrow
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Inorganic Salt Storage
• Inorganic Salt Storage
• Calcium
• Phosphate
• Magnesium
• Sodium
• Potassium
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7.2 Clinical Application
Osteopenia and Osteoporosis:
Preventing “Fragility Fractures”
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7.5: Skeletal Organization
• The actual number of bones in the human skeleton
varies from person to person
• Typically there are about 206 bones
• For convenience the skeleton is divided into the:
• Axial skeleton
• Appendicular skeleton
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7.3 Clinical Application
Disorders of the Vertebral Column
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7.8: Thoracic Cage
• The thoracic cage includes the ribs, the thoracic
vertebrae, the sternum, and the costal cartilages that
attach the ribs to the sternum.
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7.13: Lifespan Changes
• Decrease in height at about age 30
• Calcium levels fall
• Bones become brittle
• Osteoclasts outnumber osteoblasts
• Spongy bone weakens before compact bone
• Bone loss rapid in menopausal women
• Hip fractures common
• Vertebral compression fractures common
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Important Points in Chapter 7:
Outcomes to be Assessed
7.1: Introduction
Discuss the living tissues found in bone even though bone appears to
be inert.
7.2: Bone Structure
Classify bones according to their shapes and name an example from
each group.
Describe the macroscopic and microscopic structure of a long bone
and list the functions of these parts.
7.3: Bone Development and Growth
Distinguish between intramembranous and endchondral bones and
explain how such bones develop and grow.
Describe the effects of sunlight, nutrition, hormonal secretions, and
exercise on bone development and growth.
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Important Points in Chapter 7:
Outcomes to be Assessed
7.4: Bone Function
Discuss the major functions of bone.
7.5: Skeletal Organization
Distinguish between the axial and appendicular skeletons, and name
the major parts of each.
7.6: Skull – 7.12: Lower Limb
Locate and identify the bones and the major features of the bones that
comprise the skull, vertebral column, thoracic cage, pectoral girdle,
upper limb, pelvic girdle, and lower limb.
Describe the differences between male and female skeletons.
7.13: Lifespan Changes
Describe lifespan changes in the skeletal system.