Humoral & cellural immunity done

Humoral

1. CELLS OF THE
IMMUNE SYSTEM

2. Differentiation of Stem cells into B cells and T cells

3. Bursa of Fabricius

4. CELLS OF THE IMMUNE SYSTEM

5. Cells of the Immune System
Immune System
Myeloid Cells Lymphoid Cells
Granulocytic Monocytic T cells B cells
Neutrophils
Basophils
Eosinophils
Macrophages
Kupffer cells
Dendritic cells
Helper cells
Suppressor cells
Cytotoxic cells
Plasma cells
NK cells

6. Characteristics of B cells, T cells and Macrophages

8. CD4 (T
H
) : MASTER REGULATOR
•INFLUENCE functions of all cells of
immune system
FUNCTIONALY
T
H
1 T
H
2
•IL 2, IF gamma IL4, 5,6,1O
•Cytotoxic, Inflamm B cell proliferation
•Intracellular pathogens Ab production
viruses extracellular pathog
•Cell mediated imm Humoral immunity
•Facilitate type lV hypersensitivity

9. MACROPHAGES

10. •HUMORAL
IMMUNITY

11. B CELL PROLIFERATION

12. MARKERS: B LYMPHOCYTES
•B- LYMPHOCYTES
•MATURE :
Ig on surface– IgM, IgD
Fc portion of IgG, C3, EB virus
•IMMATURE CELLS
Pre-B cells– u chains in cytoplasm

13. CLONAL SELECTION
The four basic principles of the clonal selection hypothesis
Each lymphocyte bears a single type of receptor of a unique specificity
Interaction between a foreign molecule and a lymphocyte receptor capable of binding
that molecule with high affinity leads to lymphocyte activation
The differentiated effector cells derived from an activated lymphocyte will bear
receptors of an identical specificity to those of the parental cell from which
that lymphocyte was derived
Lymphocytes bearing receptors specific for self molecules are deleted at an early
stage in lymphoid cell development and are therefore absent from the repertoire of
mature lymphocytes

14. CLONAL SELECTION
UNIQUE SPECIFICITY
LYMPHOCYTE
ACTIVATION
DIFFERENTIATED
EFFECTOR CELL

15. Summary of Humoral Immunity

18. HUMORAL IMMUNE RESPONSE
(Cooperation of cells)

19. B-CELL AS ANTIGEN PROCESSING CELL

21. •CELL MEDIATED
IMMUNITY

22. MARKERS:T LYMPHOCYTES
•T- LYMPHOCYTES: MATURE CELLS
•Surface antigens detected by Specific monoclonal
antibodies---
CLUSTER DIFFERENCIATION : CD
T- helper cells: TH– CD4
+

T- delayed type :TD – CD4-
T- suppressor cells: TS– CD8
-
T – cytotoxic type: TC– CD8+
MHC CLASS 1= CD8 MHC CLASS II=CD4
• T - IMMATURE CELLS
Prothrombocytes – Tdt – terminal deoxynucleotidyl
Immature thrombocytes -- Tdt transferase

23. •CD4 (T
H
) : MASTER REGULATOR
•INFLUENCE functions of all cells of immune system

FUNCTIONALLY

TH1
IL 2, IF gamma
Cytotoxic, Inflammatory
Intracellular pathogens
Cell mediated immunity Facilitate
type lV hypersensitivity
Macrophages activation
Synthesis of IgG2 Antibodies
TH2
IL4, 5, 6,10
B cell proliferation
Extracellular pathogens
Humoral immunity
Synthesis of other Ig
Including IgE.

24. T- CELL RECEPTOR (TCR)

25. CMI -- CLONAL EXPANSION

26. Cell Mediated Immunity

27. Summary of cell mediated immunity

28. ACTIVATION OF HELPER T CELL

29. ACTIVATION OF CYTOTOXIC T CELL

30. CYTOTOXIC T CELLS

31. COMPARISON OF HUMORAL :
CELL MEDIATED IMMUNE RESPONSE

32. THANKS

33. CLONAL PROLIFERATION OF T CELLS