IMMUNITY Prof. Dr. A. N. Thakur MBBS(JIPMER), MD(AIIMS ) Dept. of Pathology NMCTH, Birgunj
Constant surveillance of the body Recognition of foreign material Destruction of entities deemed to be foreign Functions of Immune system
Types of Immunity
Cells of Immune System
Two major populations of T cells mediate cellular immunity. CD4 cells (T4 cells) are primarily helper T cells (TH) CD8 cells (T8 cells) are cytotoxic T cells ( Tc ) that destroy cells harboring foreign antigen Other types of T cells are: Suppressor T cells ( Ts ) Memory T Cells
Organs of Immune System
Hypersensitivity Reaction
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Mechanism of Type II Hypersensitivity Three different antibody dependent mechanisms are involved in this type of reaction : Complement dependent reaction Antibody dependent Cell- mediated Cytotoxicity ( ADCC ) Antibody mediated Cellular Dysfunction
Complement- dependent Reaction Two mechanisms : Opsonization Direct lysis