Inclusion bodies

INCLUSION BODIES

1. INCLUSION BODIES

2. What are inclusion bodies? Inclusion bodies are aggregates of stainable substances in the nucleus or cytoplasm.

3. How are inclusion bodies formed? Inclusion bodies are mostly formed due to viral multiplication or genetic disorders in human beings

4. Viral inclusion bodies Intra cytoplasmic Intra nuclear Both intra cytoplasmic & Intra nuclear

5. Intracytoplasmic Henderson-Peterson bodies in Molluscum Contagiosum Negri bodies in Rabies Guarnieri bodies(B type inclusion bodies) in Small Pox

6. Intranuclear Acidophilic Cowdry Type A Varicella Zoster Virus Herpes Simplex Virus Yellow Fever Virus (Torres bodies) Cowdry Type B Polio Basophilic Cowdry Type B Adenovirus Cytomegalovirus - Owl eye

7. Intranuclear and Intracytoplasmic Human Herpesvirus 6

8. Inclusion bodies in Red Blood Cells Developmental Howell Jolly Bodies Basophilic Stippling's Pappenheimer bodies Cabot Rings Polychromatophilic Red Cells Hemoglobin Precipitates Heinz bodies Hemoglobin H inclusions Protozoal   Malaria Babesia

9. Inclusion bodies in skin conditions Asteroid bodies - Sporotrichosis Cowdry A - Herpes Simplex Donovan bodies - Granuloma Inguinale Dutcher bodies - Multiple Myeloma, Primary cutaneous marginal zone lymphoma Pustulo -ovoid bodies - Granular cell tumor Medlar bodies - Chromoblastomycosis Michaelis – Gutmann bodies - Malakoplakia Rocha Lima bodies - Verruga peruana Russell bodies - Multiple myeloma Rhinoscleroma bodies Verocay bodies - Schwannoma Virchow bodies - Leprosy

10. Councilman bodies Eosinophilic bodies found in the liver in the following cases Yellow fever Acute Viral hepatitis Viral Hemorrhagic Fever

11. Dohle bodies Dohle bodies are basophilic inclusions found in cytoplasm of neutrophils and are thought to be remnants of rough endoplasmic reticulum. Burns Infections Physical trauma Neoplastic diseases Wissler’s disease May- Hegglin anomaly Chédiak - Steinbrinck -Higashi’s syndrome

12. Other examples Collins bodies - Familial encephalopathy with neuroserpin inclusion bodies Halberstädter-Prowazek bodies - Inclusion bodies in conjunctival epithelial cells in Chlamydia trachomatis Lafora bodies - Lafora progressive myoclonic epilepsy or MELF Inclusion bodies in ballooned or swollen neurons containing tau proteins in Pick's disease and Corticobasal degeneration Birbeck granules (cytoplasmic organelle) - Langerhans Cell Histiocytosis ( Histiocytosis X) Inclusion bodies in Huntington's disease - due to mutant Huntingtin protein Inclusion bodies in muscle biopsy of Hereditary inclusion body myopathy Lewy bodies in Parkinsonism - made of alpha- synuclein associated with ubiquitin, neurofilament protein, alpha B crystallin and tau proteins. Lewy bodies may occasionally be surrounded by neurofibrillary tangles Papp-Lantos bodies - Glial Cytoplasmic Inclusion bodies used in post mortem diagnosis of Multiple System Atrophy Mallory's Hyaline - Alcoholic Liver Disease

13. Auer rods or Auer bodies - found in cytoplasm of leukemic blasts. M2 and M3 of Acute Myeloid Leukemia, high grade myelodysplastic syndromes and myeloproliferative syndromes. Schuffner's dots - multiple brick red dots found in RBCs with Plasmodium Vivax infection Inclusion bodies in granulocytes in May– Hegglin anomaly also known as Dohle leukocyte inclusions with giant platelets and macrothrombocytopenia with leukocyte inclusions Gamna -Favre bodies seen in Lymphogranuloma venereum due to Chlamydia trachomatis(L1, L2, L2a or L3 serovars ) Cytoplasmic inclusion bodies in Batten disease(the most common neuronal ceroid lipofuscinosis ) in neurons of cerebral cortex. Nuclear inclusion bodies in Lead and Bismuth poisoning. Giant inclusion bodies in Chediak Higashi Syndrome. B-type inclusion bodies in cytoplasm of epidermal cells in Tanapox virus infections. Inclusion bodies in Pseudo-Hurler polydystrophy ( Mucolipidosis III) Nuclear inclusion bodies in Subacute sclerosing panencephalitis in neurons and glial cells Schaumann bodies - inclusion bodies found in sarcoidosis and berylliosis in cytoplasm of giant cells, contains calcium.

14. Calcium containing inclusion bodies Psammoma bodies Michaelis–Gutmann bodies Schaumann bodies

15. Psammoma bodies in Tumors Papillary thyroid carcinoma Papillary renal cell carcinoma Ovarian papillary serous cystadenocarcinoma Endometrial adenocarcinoma (Papillary Serous Carcinoma) Meningiomas Mesothelioma Somatostatinoma Prolactinoma

16. Psammoma bodies in Benign Conditions Endosalpingiosis Psammomatous melanotic schwannoma Melanocytic nevus