Information about grinder machine according to RSBK.

This ppt is present all information about grinder machine under RSBK in 2nd professional BAMS.

1. G rinders

2. 01 Definition G rinders are machines use to reduce the substance into coarse particles or fine powder.

3. 02 Principle B ased on the reduction of particle size through mechanical force.

4. E nd R unner M ill D isintegrator C one M ills Types of Grinders

5. B all M ill H ammer M ill E dge R unner M ill

6. Grinders are crucial for reducing the size of active pharmaceutical ingredients (APIs) and other components to a desired and consistent particle size. Control over particle size is vital as it directly influences drug performance, dissolution rates, and bioavailability. Uniformly ground particles lead to improved drug dissolution, ensuring that the medication is released and absorbed effectively in the body. This is particularly important for drugs with low solubility or those intended for controlled release. Grinders contribute to the uniform blending of different ingredients in drug formulations, promoting consistency in the final product. Consistent formulation is essential for ensuring the efficacy and safety of pharmaceuticals. P artical size control E nhance d rug dissolution F ormulation consistency I mportance of G rinders in P harmaceutical process :

7. I mpact S hear C ompression 01. 02. 03. . Example: Tablet presses use compression to form pharmaceutical tablets by compacting granulated material. Example: Hammer mills utilize impact to crush and pulverize materials, creating finer particles. Example: Colloid mills use a rotor-stator arrangement to create shear forces, resulting in the breakdown of particles in liquid or semi-liquid formulations . H ow mechanical forces are applied for size reduction :

8. particle size variation heat generation cohesive and sticky materials noise and vibration 01. 03. 02. 04. Achieving consistent and uniform particle size is a challenge, as variations can affect drug dissolution and bioavailability. c Grinding processes can generate heat, potentially affecting the stability of thermally sensitive drugs or causing undesired changes in formulations. Some pharmaceutical materials exhibit cohesive and sticky behavior, leading to clogging, increased wear on equipment, and difficulties in achieving desired particle size. t. Excessive noise and vibration can be undesirable for both equipment operators and the overall manufacturing environment. .

9. grinding influences development of various dosage form Granulation Process: Grinding is often involved in the granulation process, where raw materials are broken down into smaller particles before being compressed into tablets.Uniformity : Achieving a consistent particle size through grinding ensures uniformity in tablet weight, content, and dissolution rates. 01. tablets .

10. s. Powder Filling: Grinding is used to produce fine powders that can be accurately filled into capsules.Bioavailability : Fine grinding enhances the bioavailability of drugs, ensuring efficient absorption when administered in capsule form. 02 capsules

11. Particle Size Reduction: Grinding is employed to reduce particle size in suspensions, improving stability and preventing settling.Homogeneity : Uniformly ground particles contribute to the homogeneity of the suspension, ensuring consistent dosing.s . 03 suspension s

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