Insulin mechanism action , insulin receptor ,insulin mode of action insulin action mechanism

Insulin hormone action mechanism

1. INSULIN Group-04

2. Abdul Hakim ASH2223028M Razibul Hasan MUH2223031M Jannatul F erdous BBH2223029F Ariful Mawla Meshkat ASH2223033M Hafsa Mahbuba BKH2223030F Tanzim Mahjabin BKH2223034F

3. Introduction & History

4. From latin word insula , meaning “island.” Peptide hormone Produced by beta cells of the pancreas A chemical messenger. . Regulates the level of sugar (glucose) in the blood. What is insulin?

5. History : 1889 : Oskar Mankowski and Joseph von Mering removed the pancreas of a dog. ↓ 1893 : The cluster of cells within the pancreas is named the 'Islets of Langerhans '. ↓ 1901 : The source of insulin was found. ↓ 1921 : Dr. Fredrick Banting and Macleod discovered insulin from dog's pancreas. ↓ 1922 : Leonard Thompson becomes the first person to receive insulin to treat diabetics. ↓ 1923 : Banting and Macleod was awarded the Nobel Prize in Physiology and Medicine.

6. Characteristics & Structure

7. Characteristics PolyPeptide Hormone. Secreted by ẞ-cells in the islets of langerhans of pancreas . Regulates the metabolic activity of carbohydrates, fats and Proteins . Anabolic Hormone . 1st hormone >>> isolated, purified and synthesis . 1st hormone to sequence . 1st Hormone to be produced By DNA technology.

8. STRUCTURE OF INSULIN Insulin is a protein comprising of 2 polypeptide chains: Chain A with 21 amino acid residues Chain B with 30 amino acid residues Chains A & B are linked by disulphide bridges. A-chain contains an intra-chain disulphide bridge linking residue 6 and 11. C-chain connects A & B chains. C-chain is liberated along with insulin after breakdown of proinsulin .

9. Factor effect insulin secretion & Effect of insulin on target tissue

10. Factors effecting insulin secretion:

11. Adipose Tissue Muscle Liver Brain Intestine Kidney Effect of Insulin on Target Cell

12. TOPIC Primary functions of Insulin Biosynthesis of Insulin

13. Your text here FIGURE: Synthesis of Insulin

14. Action of Insulin

15. On Carbohydrate M etabolism Muscle and fat muscles: cells absorb glucose from the blood, lowering blood glucose levels Liver: Stimulates glycogenesis Inhibits gluconeogenesis On Lipid Metabolism Fat storage: Promotes the synthesis and storage of fat in adipose tissue. Inhibition of lypolysis : Inhibits the breakdown of stored triglycerides.

16. On Protein Metabolism Protein synthesis: Stimulates the uptake of amino acids into cells and promotes protein synthesis Inhibition of protein degradation: Inhibits the breakdown of proteins into amino acids for preserving muscle mass and overall stores of protein in the body. Electrolyte balance Potassium: Stimulates the uptake of potassium into cells prevent hyperkalemia (elevated potassium levels in the blood).

17. Disorder of Insulin and It’s treatment

18. Brands name of Insulin Tresiba Apidra