Insulin update.pptx and is pre mixed form

Insulin

1. Premixed Insulin https://www.instagram.com/luvly_romantic_vdos/p/BvEozNWgaPB/?utm_source=ig_share_sheet&igshid=ehb91hbuodd6

2. Premixed Insulin Premixed Insulin is the combination of two insulins mixed together:one insulin that is short acting or fast acting plus one insulin that is intermediate acting .

3. Short acting insulin Regular ( soluble insulin ) : Short acting, soluble, crystalline zinc insulin. Forms hexamers; after s.c.injection,it is slowly absorbed --  onset of action is within 30 min; administered 30-45 min before meals Duration of action is 6-8 h. Available as 40,100 and 500U/ml Can be administered by s.c,i.m and i.v routes.

4. Intermediate acting insulin NPH (neutral protamine hagedorn) or isophane insulin . Intermediate acting insulin. . Insulin complexed with protamine and zinc ; dissociates slowly on s.c administration--  onset of action is delayed and duration of action is 10-20h . .cloudy solution . Given s.c. Once or twice daily.

5. Long acting insulin Insulin glargine on s.c.administration: slowly absorbed-  delayed onset of action with peakless plasma concentration. Administered once daily. Cannot be mixed with other human insulins because of its acidic pH Lower risk of nocturnal hypoglycemia than NPH insulin. Should be avoided in pregnant diabetes. . Insulin detemir On s.c injection : binds to albumin in blood  prolonged duration of action. Minimal peak level.usually given twice daily.

6. Advantages More accurate dosing Lesser injection Pen devices administer premixed insulin.

7. Disadvantages Fine tooling may not be possible Strict meal pattern Nocturnal hypoglycemia.

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