Introduction of sodium cromoglycate

itx a summarized introduction of sodium cromoglycate which is a mast cell stablizer drug

1. Sodium cromoglycate Muhammad Owais Roll no : 130450 Presentation #2 for pharmacology

2. INTRODUCTION: Sodium Cromoglycate also known as Sodium Cromoglicate. a synthetic non-steroidal anti-inflammatory drug, inhaled to prevent asthmatic attacks and allergic reactions . Sodium cromoglycate is traditionally described as a mast cell stabilizer , and is commonly marketed as the sodium salt, sodium cromoglycate or cromolyn sodium Sodium cromoglycate:

3. HISTORY: Sodium cromoglycate (SCG) was discovered in 1965 by the late Dr. Roger Altounyan (who was himself a lifelong asthma sufferer) developed by Fisons Pharmaceuticals for use as an inhaled drug in asthma, primarily of allergic origin. The drug was selected after over 200 compounds had been tested by Altounyan

4. MECHANISM OF ACTIONS: Sodium cromoglycate acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. Cromolyn sodium probably interferes with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.

5. USES OF SODIUM CROMOGLYCATE: BRONCHIAL ASTHMA ALLERGIC RHINITIS ALLERGIC CONGUCTIVITUS

6. PREPARATION AND DOSAGE: AS AN INHALER: (Fintal inhaler) PREPARATION: 1mg metered dose inhaler. DOSE: 2 puffs (Q.I.D) AS A NASAL SPRAY : (Fintal nasal spray) PREPARATION : 2% aqueous solution DOSE: 2 squeezes in each nostrils (Q.I.D) AS EYE DROPS: (Fintal eye drops) PREPARATION : 2% aqueous solution DOSE : 1 drop in each eye (Q.I.D)

7. ADVERSE DRUG REACTION: Skin rashes Bronchospasm Throat irritation dizziness Flare up of skin Arthralgia Sometime urticaria

8. PHARMACOKINETIC OF SODIUM CROMOGLYCATE ABSORPTION: poorly absorbed orally i.e. 0.5% but in the form of aerosol its absorption rate increased up to 1.5% ELIMINATION: most of absorbed drug is excreted unchanged by liver & kidneys within a few days & none appears to undergo metabolic degradation.

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