Introduction to Galaxy QuasIR Product Line 05-06-2023.pptx

Nir descriptions

1. Introducing the Galaxy Scientific QuasIR FT-NIR Product Line THE MEASURE OF INNOVATION www.galaxy-scientific.com From the Leaders in High Performance Portable NIR Solutions

2. The Galaxy Team We have a dedicated team of technical and business professionals with over 150 years of combined experience in the molecular spectroscopy industry. Executive leadership from the most successful and fastest growing companies Expertise in all facets of developing and running analytical businesses Vast expertise in the science and application of spectroscopy technology Extensive experience in global markets Decades of experience in developing, deploying and servicing NIR customers Passion for innovation and solving problems

3. Dennis Merrill- CTO BS Eletrical Engineering MBA - MIT 20+ years experience including R&D manager for Thermo Nicolet & Thermo Portable Analytical. Innovator in embedding computing and digital processing Qian Wang- President PhD Boston University VP Bruker Optics China 25+ years of applied spectroscopy experience Lead successful large scale projects with Chinese SDFA Respected figure with key relationshiops in the US & Chinese analytical business One of the key person to build Bruker Optics business in USA and Asia Paciific from 5 to 40+ millions Richard Jackson - CEO PhD Univ. of Leeds Recognized authority in spectroscopy sciences and the applied use of spectroscopic technologies 25+ years of experience in the engineering and application of molecular spectroscopy products One of the key person to build Bruker Optics Business in USA from 3 to 20 Millions.

4. The Galaxy Facility We are in a 6,000 sq. ft. office located in Nashua, NH and equipped with full research and development capabilities including development laboratories, a rapid-turn prototype machine shop and test facilities. Complete manufacturing operations include inventory management, assembly, loading dock and packaging, as well as a multi-media and marketing generation studio.

5. The Galaxy Mission Until recently, NIR systems have been either high performance, for laboratory use, “or” portable, for field use, but not both. Our vision is to offer a new, high performance, portable NIR solution with both the analytical performance and portability required for todays market. We are committed to provide not just instruments, but analytical solutions for important problems in public safety and for applications in different industries, such as pharmaceutical, food, agriculture, chemical, energy and environmental.

6. High Performance High resolution Broad Spectral Range Heavy/Large/Not Easy to Field Operate Light/Small/Easy to Operate Low Performance, Low resolution Narrow Spectral Range High Performance, High resolution Broad Spectral Range Light/Small/Easy for field operation Unaddressed Market Needs for NIR Instrumentation

7. QuasIR Principle Design Criteria Portable Instrument must be compact and light enough to be easily hand carried Instrument must be capable of operation on battery power High performance Resolution Wide spectral range High stability High reproducibility among different instruments Design for field conditions Instrument must be able to operate in any orientation Instrument must operate over a wide temperature range Instrument must withstand shock and vibration Low cost of Ownership All Components must have very long lives Any components that may fail during the life of the instrument must have a low replacement cost

8. Galaxy Scientific Analytical Performance Galaxy Scientific Portability Portability to go outside the lab to the point-of-need Analytical Performance for demanding applications Our products combine high performance and portability so you get the results you need… where you need them. A New Kind of Portable Solution

9. The QuasIR ™ Product Line QuasIR TM 2000 Fiber Optic FT-NIR QuasIR TM 3000 Integrating Sphere FT-NIR QuasIR TM 4000 Transmission and Integrating Sphere FT-NIR QuasIR TM 1000 Transmission FT-NIR QuasIR TM 2000E Fiber Optic FT-NIR New! New!

10. The QuasIR ™ Product Line

11. QuasIR TM 2000 FT-NIR with Fiber Optic Interface SMA 905 fiber optic connectors support a wide range of Galaxy and 3 rd party fiber optic probes Compatible with Galaxy patterned probe technology Direct calibration transfer between QuasIR TM systems Calibration transfer service from Foss, Bruker, Buchi and other NIR brands

12. Patterned Probe Technology Galaxy’s patterned probe technology results in a high signal-to-noise ratio and better probe-to-probe reproducibility. All the launch fibers are surrounded by collection fibers which maximizes the amount of reflected light collected by the probe Reproducible fiber layout in the probe MS-2000 1.5 meter solids probe Launch Fiber Collection Fiber

13. Patterned Probe Technology Nitroglycerin tablets Measured with 8 diffuse reflectance probes 3 DRIFT Probes Random fiber Same manufacturer 5 Galaxy DRIFT probes proprietary patterned fiber design Five new probes Solids probe with random fibers Solids probe with p roprietary patterned design

14. QuasIR TM 3000 FT-NIR Large Area Integrating Sphere The QUASIR TM 3000 is configured with a gold coated integrating sphere. Ideal for food and agricultural applications Direct calibration transfer between QuasIR TM systems Calibration transfer service from Foss, Bruker, Buchi and other NIR brands Shown with available rotating sample cup accessory

15. QuasIR TM 3000 FT-NIR Sampling Innovation The QuasIR TM 3000 features a 23 mm diameter extended sampling area which offers > 5 times larger sampling area vs our FT-NIR competitors. Increased sampling area = More consistent results QuasIR TM 3000 Sample Spinner and sample cups Quasir TM 3000 Competitor 23 mm Sampling Area

16. QuasIR TM 3000 FT-NIR Sample Cups and Adapters Quartz Cup 98 mm diameter Low OH Quartz Window Petri Dish and Beaker Adapter 98 mm diameter For low cost glassware or polystyrene dishes (optional) Good for oily or messy samples Can be washed in bulk

17. QuasIR TM 3000 FT-NIR Galaxy QuasIR TM 3000 vs Foss DS2500F QuasIR TM 3000 vs Foss DS2500F Parameter QuasIR 3000 Foss DS2500F Size (W x D x H) 440x 241 x 145 mm 375 x 490 x 300 mm Weight 8.83 kg (19.5 lbs ) 27 kg (59.5 lbs ) Resolution 4 ± 0.1 cm -1 (< 0.78nm) 8.75 ± 0.1 nm Spectral range 785-2500 nm 1100-2500 nm

18. QuasIR TM 3000 FT-NIR Galaxy QuasIR TM 3000 vs Bruker Tango QuasIR TM 3000 vs Foss DS2500F Parameter QuasIR 3000 Bruker Tangp Size (W x D x H) 440x 241 x 145 mm 438 x 292 x 175 mm Weight 8.8 kg (19.5 lbs ) 18.6 kg (40.1 lbs ) Resolution 4 ± 0.1 cm -1 8 cm-1 ± 0.1 cm-1 Spectral range 12,000-4000 cm -1 11500-4000 cm-1

19. QuasIR 4000 with Two Measurement Channels The QuasIR 4000 is configured with two measurement channels. Large sampling area for Integrating Sphere channel: 23mm in diameter, 5 times larger than leading competitors Optional spinner to further increase the sampling area Temperature controlled liquid transmission measurement channel can not only heat up to 100°C, but also cool down to 20°C. Direct calibration transfer between QuasIR systems Calibration transfer service from Foss, Bruker, Buchi and other NIR brands

20. Better Analysis of Liquids Wish you had a better way to accommodate liquid samples? Now you have it. QuasIR 4000 offers two different liquid sampling solutions Transflectance liquid attachment (QuasIR 3000 & QuasIR 4000) Heated liquid transmission cell (QuasIR 4000 only) It’s like having 2 analyzers in one!

21. QuasIR 4000 with Compact Design Compact, Light and Easy to Use QuasIR 4000: 8.8kg vs. Bruker MPA same configuration: 30kg, 70% Lighter. QuasIR 4000: 44.0x24.1x14.5cm vs. Bruker MPA base unit 40x58.9x26.2cm, 75% Smaller. Similar performance, such as S/N ratio, resolution, wavelength accuracy etc. More ruggedized for harsh environment QuasIR has Lower maintenance cost 20,000+ hr MTBF Light Source 10 + year laser lifetime QuasIR 4000 MPA Base

22. QuasIR 4000 with Two Measurement Channels The QuasIR 4000 is configured with two measurement channels. Large sampling area for Integrating Sphere channel: 23mm in diameter, 5 times larger than leading competitors Optional spinner to further increase the sampling area Temperature controlled liquid transmission measurement channel can not only heat up to 100°C, but also cool down to 20°C. Direct calibration transfer between QuasIR systems Calibration transfer service from Foss, Bruker, Buchi and other NIR brands

23. QuasIR TM 2000E FT-NIR Example: mining

24. QuasIR TM 2000E FT-NIR designed for continuous measurement of the chemical composition of material transported on a conveyor belt, through a pipe, or in a chute Various illuminators available Different spot size Different working distance

25. QuasIR with Compact Design Compact, Light and Easy to Use QuasIR 4000: 8.8kg vs. Bruker MPA same configuration: 30kg, 70% Lighter. QuasIR 4000: 44.0x24.1x14.5cm vs. Bruker MPA base unit 40x58.9x26.2cm, 75% Smaller. Similar performance, such as S/N ratio, resolution, wavelength accuracy etc. More ruggedized for harsh environment QuasIR has Lower maintenance cost 20,000+ hr MTBF Light Source 10+ year laser lifetime QuasIR 4000 MPA Base

26. Galaxy Advantages PermAlign TM FT Technology Compact, Designed for Portability QuasIR TM 2000 FT-NIR QuasIR TM 4000 FT-NIR 7.1 kg 8.8 kg

27. Galaxy Advantages Portability QuasIR TM was engineered for laboratory or field use. No longer does your analysis system need to be confined to a laboratory environment. QuasIR TM fits conveniently in an FAA approved carry-on traveling case. QuasIR TM can operate from mains power, vehicle power, or an external battery.

28. Galaxy Advantages Low Cost of Ownership QuasIR TM uses a t emperature stabilized solid-state laser Compact Excellent wavelength stability Typical lifetime (10+ years) greater than life of instrument Low power consumption and heat dissipation QuasIR TM uses a special compact lamp Typical life 20,000+ hours Inexpensive replacement cost User replaceable Wear free interferometer drive with 10 year warranty (factory replacement) User replaceable desiccant

29. QuasIR TM Performance Specifications Performance Specifications Value Value Wavelength Range 12,800 - 4,000 cm -1 785 - 2,500 nm Spectral Resolution Better than 4 cm -1 < 0.78 nm @ 1392 nm Wavelength Accuracy < 0.1 cm-1 @ 7181.68 cm -1 < 0.019 nm Wavelength Repeatability < 0.05 cm-1 @ 7181.68 cm -1 <0.009 nm Photometric Accuracy Better than 0.1% T   Noise Better than 20 micro au Low detection limit Detector TE cooled InGaAs   Reliability Specifications Value Benefit Laser Life > 10 years Low downtime & ownership Costs NIR Source Life > 20,000 hours, user replaceable Low downtime & ownership Costs Desiccant User replaceable Low ownership Costs

30. Main Optical Components

31. Galaxy Advantages PermAlign TM FT Technology FT-NIR technology offers significant advantages over other types of NIR including: High spectral resolution High signal-to-noise ratio High & inherently stable wavelength accuracy Full spectral range In addition, all models in the QuasIR product line utilize Galaxy’s PermAlign TM Fourier Transform Technology. PermAlign TM technology takes FT-NIR to the next level by offering incredibly high performance in a small portable design. Permanent Interferometer Alignment Small & Lightweight Design Robust Field Operation Patented Permanently Aligned Interferometer Block

32. Galaxy Advantages PermAlign TM FT Technology Interferometer in a traditional FT instrument uses a flat mirror , which is sensitive to vibration and mechanical error Source of Scan Error Moving mirror mechanism mechanical error Vibration can cause tilt and shear of moving mirror

33. Galaxy Advantages PermAlign TM FT Technology Commonly Used Method to Solve Scan Error : use Cube-Corner mirror instead of flat mirror Cube-corner moving mirror is immune to tilt But it can not correct the error caused by shear The shearing caused by vibration and mechanical error can result in errors when beams are recombined at the beam-splitter.

34. Galaxy Advantages PermAlign TM FT Technology Our interferometer design: Add a flat mirror in front of cube-corner mirror Immune to tilt and shear Insensitive to vibration Never needs alignment

35. Interferometer Flexure based drive Highly uniaxial motion Frictionless “Infinite” life Quartz interferometer block Permanently aligned Insensitive to temperature

36. Thermal Management Create thermal pathways inside instrument to move heat to desired location, where it can be dissipated Source heatsink Main Heatsink – designed for passive cooling

37. Thermal Management Reduce power consumption Low power (5W) source, 20,000 hr MTBF Solid state laser. Low power consumption Very long life

38. Thermal Management Effectiveness of thermal design tested over wide temperature range Operating temperature range 0°C - 40°C

39. Method Development & Transfer Services Galaxy Scientific offers both method development and transfer services. We can help you to build new calibration models and to transfer existing calibration models from your old equipment to a new QuasIR TM system.

40. Spectral Compatibility with a FT-NIR S pectrometer from a different FT-NIR V endor Original spectrum of a tablet: Measured with Galaxy QuasIR 2000 Measured with Bruker Matrix-F

41. Spectral Compatibility with Bruker 1 st derivative spectrum of the previous spectra Measured with Galaxy QuasIR 2000 Measured with Bruker Matrix-F

42. Direct Calibration 1 : A Joint Study with a Customer Using a Bruker Ident Model Collect spectra of the same tablet on 3 Bruker Matrix-F systems (Bruker 1-3) and 4 QuasIR 2000 systems (New 1-4), then use established original Bruker Idnet model to do qualitative analysis. All passed the test and further more, the hit qualities of QuasIR spectra are even smaller than that of Bruker spectra.

43. Direct Calibration 1 : A Joint Study with a Customer Using a Bruker PLS Model Average predicted value of spectra measured on Bruker Matrix-F is 64.3% with STD of 0.36%. Ave predicted value of spectra measured on QuasIR is 64. 5 % with STD of 0.34% The PLS model used was an established PLS model developed with spectra measured with Matrix-F several years ago. There is no outlier detected and the RMSEP of the model is 2.26%.

44. Ave. of QuasIR = 64. 5 % STD = 0.34% No outliers Ave. of Bruker = 64. 3 % STD =0.36% Quantitative Analysis Result Using Bruker Quant Model

45. Direct Calibration 2: A Joint Study with a Customer Using a Bruker PLS Model Sample used: 4 Poly(ethylene-co-vinyl acetate) samples with approximate vinyl acetate concentrations at 12%, 18%, 25% and 40% were used in this study. Instrument used: Samples were measured with 4 Bruker Matrix-I, 9 Galaxy Scientific QuasIR 3000 and 1 Bruker Vector 22N-I I sphere channel equipped with rotating cup on each instrument Resolution of 4cm -1 Quant Model used: Customer developed Poly (ethylene-co-vinyl acetate) calibration with spectra collected on tens of Bruker Matrix-I was used to directly predict vinyl acetate (VA%) concentrations of spectra obtained in this study using multiple instruments as mentioned above. Method root mean square error of cross validation (RMSECV) is 0.44% while root mean square error of prediction (RMSEP) is 0.4%. Each sample was measured 3 times on each instrument, the average predicted values of each sample with each type of instrument along with other statistic values were listed in the following slide.

46. Original Spectra of the same co-polymer samples Poly(ethylene-co-vinyl acetate) with 12% Vinyl acetate (VA) 5 x Matrix-I 8 x Q3000 1 x Vector 22N

47. 2 nd Derivative Spectra of the same co-polymer samples Poly(ethylene-co-vinyl acetate) with 12% Vinyl acetate (VA) 5 Matrix-I 8 QuasIR 3000 1 Vector 22N-I

48. 7600 to 5444 cm-1 SNV; one Matrix-I to build the model. Predict others.

49. 7600 to 5444 cm-1 SNV; one Matrix-I to build the model. Prediction, : magenta 4 x Matrix-I, blue 1 x Vector, green- 8 x Q3000

50. Advanced-Identification Package Often manufacturers are interested in ingredients, adulterants, or contaminants present at concentrations too low for standard NIR approaches. Advanced-Identification is a patent-pending targeted screening software tool that allows quick screening and semi-quantitative results for concentrations as low as 0.01%. Advanced-Identification extends the use of NIR to further reduce supply chain risk and protect your brand integrity.

51. Advanced-Identification Package Advanced-Identification – ViewThrough Technology Spectra of pure aspartame (blue) compared to the spectrum of a manila envelope (magenta) and aspartame sampled through a manila envelope (green)

52. Advanced-Identification Package Advanced-Identification – ViewThrough Technology Extracted spectrum from aspartame through a manila envelope produced by Advanced-ID can be compared to pure aspartame and dextrose

53. Advanced-Identification Package Advanced-Identification – ViewThrough Technology Comparison of results of simple correlation to the Advanced-ID™ method where the extracted spectrum (after packaging removal) is correlated to the pure material spectra. Green: pass Red: fail Yellow: Pass, r 2 <0.9

54. Our customer Eurofins QTA

55. Eurofin QTA

56. Why QuasIR TM FT-NIR Products Portability: suitable for lab and field use Small Light Multiple power sources Rugged optical design Variety of carry cases available Operate in any orientation Small and Light Save valuable bench space in lab Easy to move, even between sites Low shipping costs

57. Why QuasIR TM FT-NIR Products FT-NIR performance High and variable resolution Full NIR spectral range with no loss of information Excellent wavelength stability Low noise PermAlign TM optics technology Robustness Reliability High performance Insensitive to vibration, temperature and orientation Small and lightweight design Permanent alignment

58. Why QuasIR TM FT-NIR Products Large sampling area Good for inhomogeneous samples Sample spinner accessory Further increases sampling area Integrated liquids analysis One instrument for both transmittance and diffuse reflectance measurements Patterned probe design Better reproducibility from probe to probe

59. Why QuasIR TM FT-NIR Products Advanced Ingredient Screening Patent pending AdvancedID TM algorithm for better screening and adulteration analysis Lower detection limit Calibration Development and Calibration Transfer Services Scientists with decades of experience Better Customer Support & Satisfaction Low Cost of Ownership Consumable parts have very long lifetime Compact design makes depot service possible Cheaper, because no travel costs Faster, because no waiting time

60. Applications in Food & Agriculture Dairy Protein, Moisture, Fat(s) Total Solids/Solids-not-fat Casein, Urea, Lactic acid, Citric acid, Lactose, Glucose, Sucrose Screening/Adulteration Edible Oils Fatty Acids Moisture Oxidation Saturation Authenticity Meat Fat Protein Moisture Collagen Salt Beer - Wine - Liquor Ethanol, Water Sugar, Starch pH Value, Acids Organic Acids Amylopectin Maltose Fermentation Tobacco Moisture Nicotine Total and Reducing Sugar Ash Classification & Grading Animal Feed Moisture Protein Fat Fiber Digestabilty Coffee - Tea Caffeine Chlorogenic acid Free amino acids Polyphenols Origin & Grading Baked Goods Fatty Acids Moisture Oxidation Saturation Authenticity Ethanol Fermentation Process Glucose & Lactose % Ethanol DDGS Quality Control

61. Applications in Pharmaceuticals and Petrochemicals Polymers Density, Hardness, Viscosity Molecular Weight and tacticity Saponification & OH Value Additives Refining Octane Cetane Aromatics Distillation Range Flash & Freezing Points Additives Pharma Raw Material Quick Raw Material Identification for Pharma, Nutraceutical, and Dietary Supplement Manufacturers Counterfeit Drugs Product Authentication for Brand Protection Counterfeit Screening for Public Safety Coal Moisture Energy Content Ash Content Volatile Content Drug Manufacturing Quality Control Content Uniformity Blend Uniformity Process Analytical Technology

62. Conclusion For more information, please contact us: Visit our website - www.galaxy-scientific.com Email us - [email protected] Or call to speak to one of our NIR experts at 603-821-9650 Galaxy Scientific headquarters is located in Nashua, NH (45 minutes from Boston, MA)