Ischemic stroke

Ischemic stroke

1. ISCHEMIC STROKE Dr. Syed Muhammad Ali Shah RMO/PGR Dept. of Medicine ABSTH/NSMC

2. HISTORY OF STROKE Hippocrates first recognized stroke over 2,400 years ago. At this time stroke was called apoplexy, which means "struck down by violence" in Greek .   In mid-1600s that Jacob Wepfer - bleeding in the brain or blockage in one of the brain's blood vessels In 1928, apoplexy was divided into categories based on the cause of the blood vessel problem. This led to the terms stroke or "cerebral vascular accident (CVA)."  http://www.hopkinsmedicine.org/healthlibrary/conditions/nervous_system_disorders/history_of_stroke_85,P00223/

3. DEFINITION Stroke is defined as a syndrome of rapid onset of cerebral deficit (usually focal) lasting >24 h or leading to death, with no cause apparent other than a vascular one. Kumar & Clark’s Clinical M edicine 8th Ed.

4. Epidemiology of Stroke Stroke remains the third leading cause of death worldwide. No large scale epidemiological studies are available to determine the true incidence of stroke in Pakistan. Estimated annual incidence is 250/100,000, translating to 350,000 new cases every year. http://www.jpma.org.pk/full_article_text.php?article_id=1444

5. RISK FACTORS *Davidson’s Principles and Practice of Medicine 22 nd Ed.

6. Classification of Stroke

7. CAUSES OF STROKE

8. Pathology Ischemia of brain occurs due to thromboembolic event Reduction of blood flow reduces supply of oxygen and hence ATP. H+ is produced by anaerobic metabolism of available glucose. Energy-dependent membrane ionic pumps fail, leading to cytotoxic oedema and membrane depolarisation , allowing calcium entry and releasing glutamate. *Davidson’s Principles and Practice of Medicine 22 nd Ed

9. Pathology Calcium enters cells via glutamate-gated channels and activates destructive intracellular enzymes, destroying intracellular organelles and cell membrane, with release of free radicals. Free fatty acid release activates pro-coagulant pathways that exacerbate local ischemia. Glial cells take up H+, can no longer take up extracellular glutamate and also suffer cell death, leading to liquefactive necrosis of whole arterial territory. Davidson’s Principles and Practice of Medicine 22 nd Ed

10. Arterial Cerebral Circulation The arterial cerebral circulation is normally divided into Anterior cerebral circulation Posterior cerebral circulation http://emedicine.medscape.com/article/1916852-clinical

11. Symptoms & Signs Hemiparesis Monoparesis Hemisensory deficits Monocular or binocular visual loss Visual field deficits Diplopia Dysarthria Facial drop Ataxia Vertigo (rarely in isolation) Aphasia Sudden decrease in the level of consciousness http://emedicine.medscape.com/article/1916852-clinical

12. Stroke, April 2003, Adams et al, Management of Patients With Ischemic Stroke

13. Stroke, April 2003, Adams et al, Management of Patients With Ischemic Stroke

14. Rapid Assessment of Suspected Stroke ROSIER scale Unilateral facial weakness +1 Unilateral grip weakness +1 Unilateral arm weakness +1 Unilateral leg weakness +1 Speech loss +1 Visual field defect +1 Loss of consciousness −1 Seizure −1 Total (−2 to +6); score of > 0 indicates stroke is possible cause Exclude hypoglycaemia Bedside blood glucose testing Davidson’s Principles and Practice of Medicine 22 nd Ed

15. Investigations

16. Management General Management 1 Airway Perform bedside swallow screen and keep patient nil by mouth if swallowing unsafe or aspiration occurs Breathing Check respiratory rate and oxygen saturation and give oxygen if saturation < 95% Circulation Check peripheral perfusion, pulse and blood pressure and treat abnormalities with fluid replacement, anti- arrhythmics and inotropic drugs as appropriate Hydration If signs of dehydration, give fluids parenterally or by nasogastric tube www.pakneurology.net Davidson’s Principles and Practice of Medicine 22 nd Ed http://jama.jamanetwork.com/article.aspx?articleid=195305

17. Nutrition Assess nutritional status and provide nutritional supplements if necessary If dysphagia persists for > 48 hrs, start feeding via a nasogastric tube Medication If patient is dysphagic , consider alternative routes for essential medications Blood pressure Unless there is heart or renal failure, evidence of hypertensive encephalopathy or aortic dissection, do not lower blood pressure in first week as it may reduce cerebral perfusion. Target blood pressure in patients who are not candidates for rt -PA should have a systolic blood pressure of less than 220 mm Hg and a diastolic blood pressure of less than 120 mm Hg. A blood pressure less than these values does NOT warrant anti-hypertensive medicines. Blood pressure often returns towards patient’s normal level within first few days http://jama.jamanetwork.com/article.aspx?articleid=195305

18. Blood glucose Hyperglycemia has detrimental outcomes after stroke. It increases the chances of hemorrhagic conversion. Persistent hyperglycemia at the rate of > 200 mg / dl independently predicts stroke expansion Monitor closely to avoid hypoglycaemia Temperature Increased body temperature in the setting of acute stroke is associated with poor neurologic outcomes as raised brain temperature may increase infarct volume If pyrexic , investigate and treat underlying cause & control with antipyretics Common reasons are aspiration pneumonia, IV line phlebitis and urinary tract infection.

19. Pressure areas Reduce risk of skin breakdown Treat infection Maintain nutrition Provide pressure-relieving mattress Turn immobile patients regularly Incontinence Check for constipation and urinary retention; treat appropriately Avoid urinary catheterisation unless patient is in acute urinary retention or incontinence is threatening pressure areas Mobilisation Avoid bed rest

20. Thrombolysis IV thrombolytic therapy with recombinant tissue plasminogen activator ( rtPA ; 0.9 mg/kg to a maximum of 90 mg, with 10% given as a bolus over 1 minute and the remainder over 1 hour) is effective in reducing the neurologic deficit in selected patients Patients should receive tPA within 1 hour after arriving to the hospital but not more than 4.5 hours after the onset of ischemic symptoms. CMDT 2015 www.pakneurology.net http://jama.jamanetwork.com/article.aspx?articleid=195305

21. In patients not eligible for thrombolytic therapy, the immediate administration of aspirin 325 mg orally daily is indicated. Anticoagulant drugs ONLY be started in the setting of atrial fibrillation with warfarin (target INR 2.0–3.0) or dabigatran (150 mg twice daily) Davidson’s Principles and Practice of Medicine 22 nd Ed CMDT 2015 http://jama.jamanetwork.com/article.aspx?articleid=195305

22. Elevated intracranial pressure is managed by head elevation and osmotic agents such as mannitol . Decompressive hemicraniectomy for malignant middle cerebral artery infarctions may reduce mortality and improve functional outcome in some instances. Davidson’s Principles and Practice of Medicine 22 nd Ed CMDT 2015 http://jama.jamanetwork.com/article.aspx?articleid=195305

23. Physical Therapy Passive movements at an early stage will help prevent contractures. As cooperation increases and some recovery begins, active movements will improve strength and coordination. In all cases, early mobilization and active rehabilitation are important. Occupational therapy may improve morale and motor skills Speech therapy may help expressive dysphasia or dysarthria . CMDT 2015 www.pakneurology.net

24. Steroids Treatment with corticosteroids did not appear to show any improvement in functional outcomes of stroke survivors. Usage of steroids in these cases may elicit unwanted adverse effects such as hyperglycemia and infections. Neuroprotection and Neurotonics No single trial has shown convincing benefit of stroke neuroprotection and efficacy of intervention is doubtful. Qizilbash N, Lewington SL, Lopez- Arrieta JM. Corticosteroids for acute ischaemic stroke. Cochrane Database Syst Rev. 2002:CD000064 Lutsep HL, Clark WM. Neuroprotection in acute ischemic stroke. Current status and future potential. Drugs R D. 1999; 1:3-8 Wahlgren NG, Ahmed N. Neuroprotection in cerebral ischemia: Facts and fancies—the need for new approaches. Cerebrovasc Dis. 2004; 17 Suppl 1:153-166

25. Secondary Prevention Antithrombotic therapy Aspirin in a dose ranging from 75 to 300 mg is efficacious in stroke prevention. Clopidogrel is marginally better at increased cost and is therefore suggested in those with concomitant peripheral vascular disease and / or intolerance to aspirin. Dose adjusted warfarin is suggested in an INR 2-3 for those who have intermittent or continous atrial fibrillation. Davidson’s Principles and Practice of Medicine 22 nd Ed CMDT 2015 www.pakneurology.net http://jama.jamanetwork.com/article.aspx?articleid=195305

26. Lipid Control 1 Atorvastatin 80 mg/day significantly reduced the risk of stroke in patients who previously had a stroke or (TIA) and who had no known cardiovascular disease. Target goal for cholesterol lowering LDL-C of <100 mg/ dL and LDL-C of <70 mg/ dL for very-high-risk persons with multiple risk factors Blood Pressure Control 2’3 Mean blood pressure fall of 5 mm Hg leads to a one third reduction of stroke If BP > 130/70 mmHg 1–2 weeks after onset use thiazide diuretic and/or ACE inhibitor 1. Stroke Prevention by Aggressive Reduction of Cholesterol Levels (SPARCL) study 2. PROGRESS trial 3. Davidson’s Principles and Practice of Medicine 22 nd Ed www.pakneurology.net http://jama.jamanetwork.com/article.aspx?articleid=195305

27. Smoking Obesity Exercise- regular physical activity Dietry salt restriction www.pakneurology.net http://jama.jamanetwork.com/article.aspx?articleid=195305

28. Surgical Interventions Carotid Endarterectomy When arteriography reveals a surgically accessible highgrade stenosis (70–99% in luminal diameter) on the side appropriate to carotid ischemic attacks - operative treatment (carotid endarterectomy ) or endovascular intervention reduces the risk of ipsilateral carotid stroke CMDT 2015 http://jama.jamanetwork.com/article.aspx?articleid=195305

29. Stroke in Future Folate Supplements for Stroke Prevention 1 Among adults with hypertension in China without a history of stroke or MI, the combined use of enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke. These findings are consistent with benefits from folate use among adults with hypertension and low baseline folate levels. 1.http :// jama.jamanetwork.com / article.aspx?articleid =2205876

30. Stroke in Future Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome . http ://www.nejm.org/doi/full/10.1056/NEJMoa1414792#t=abstract