Jaknat Tablet - Complete Information Guide

Jaknat is a Janus kinase (JAK) inhibitor containing tofacitinib as its active ingredient. It is manufactured by Natco Pharma Ltd. and is primarily used to treat various autoimmune conditions by modulating immune system activity.
Jaknat (Tofacitinib) tablet belongs to the group of medicines called Janus kinase (JAK) inhibitors. It is a JAK1/JAK3 inhibitor authorised for use in several countries to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis managed under the Department of Orthopaedics), and Ulcerative colitis (managed under the Department of Gastroenterology, especially in patients who have had an inadequate response to other therapies. Jaknat tablet selectively inhibits JAK enzymes involved in the signalling pathways of pro-inflammatory cytokines, thereby reducing immune system overactivity and inflammation in autoimmune disorders. Jaknat Tablet – Uses, Side Effects, Composition, and Dosage

1. Jaknat Tablet – Uses, Side Effects, Composition, and Dosage Manufactured by:   Natco Pharma Ltd . Class:   Jaknat tablet is a Janus kinase (JAK) inhibitor containing tofacitinib

2. Jaknat is a Janus kinase (JAK) inhibitor containing tofacitinib as its active ingredient. It is manufactured by Natco Pharma Ltd. and is primarily used to treat various autoimmune conditions by modulating immune system activity. Jaknat ( Tofacitinib ) tablet belongs to the group of medicines called Janus kinase (JAK) inhibitors . It is a JAK1/JAK3 inhibitor authorised for use in several countries to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis managed under the Department of Orthopaedics ), and Ulcerative colitis (managed under the Department of Gastroenterology , especially in patients who have had an inadequate response to other therapies. Jaknat tablet selectively inhibits JAK enzymes involved in the signalling pathways of pro-inflammatory cytokines, thereby reducing immune system overactivity and inflammation in autoimmune disorders. Jaknat Tablet – Uses, Side Effects, Composition, and Dosage

3. Composition Jaknat 5mg : Tofacitinib 5mg (immediate-release) - Strip of 10 tablets Jaknat 10mg : Tofacitinib 10mg (immediate-release) - Strip of 10 tablets Jaknat 11mg XR : Tofacitinib 11mg (extended-release) - Strip of 10 tablets Medical Uses of Jaknat Tablet Jaknat is prescribed under the care of specialist departments. 1. Department of Orthopaedics Rheumatoid Arthritis (RA): Helps manage joint pain, swelling, stiffness, and prevents long-term deformity. Psoriatic Arthritis: Reduces joint inflammation and improves mobility while also controlling psoriasis symptoms. Ankylosing Spondylitis : Targets spinal inflammation, reducing stiffness and improving posture.

4. 2. Department of Gastroenterology Ulcerative Colitis: By reducing inflammation in the intestinal lining, Jaknat decreases diarrhoea , abdominal cramps, and rectal bleeding, leading to improved gut function . Mechanism of Action Jaknat works by selectively inhibiting JAK enzymes (primarily JAK1 and JAK3) that are involved in inflammatory signaling pathways. By blocking these enzymes, it: Disrupts JAK-STAT signaling cascade Reduces production of inflammatory mediators Decreases immune system overactivity Controls inflammation in autoimmune disorders

5. Primary Uses Approved Indications : Rheumatoid Arthritis (RA) - Reduces joint pain, stiffness, swelling; slows joint damage Psoriatic Arthritis - Controls joint inflammation and skin symptoms Ankylosing Spondylitis - Reduces spinal and joint inflammation, improves flexibility Ulcerative Colitis - Reduces colon inflammation, relieves abdominal pain and diarrhea Polyarticular Juvenile Idiopathic Arthritis - For children aged 2+ years Juvenile Psoriatic Arthritis - Pediatric indication Off-label Uses: Refractory systemic rheumatic diseases (SAPHO syndrome) Challenging dermatologic conditions (atopic dermatitis, alopecia areata , plaque psoriasis) Other immune-mediated inflammatory conditions

6. Dosage Guidelines Adults : RA, Psoriatic Arthritis, Ankylosing Spondylitis : 5mg twice daily (immediate-release) OR 11mg once daily (extended-release) Ulcerative Colitis : Induction: 10mg twice daily for up to 8 weeks Maintenance: 5mg twice daily Pediatric Dosing: Children 2+ years: Weight-based dosing determined by pediatric specialists Special Populations: Hepatic Impairment : Reduce to 5mg once daily (moderate impairment) Renal Impairment : Reduce to 5mg once daily if creatinine clearance <30 ml/min Elderly : No specific dose adjustment, but increased monitoring required

7. Administration Guidelines Take exactly as prescribed by physician Swallow tablets whole with water (do not crush, chew, or break) Can be taken with or without food (with food may reduce stomach upset) Take at same time each day for consistent effects If dose missed: Take as soon as possible unless close to next dose Never double doses 👉 For more Healthcare Information:  https://www.pacehospital.com/blog 👉 Book an Appointment with   Top doctors in Hyderabad, Telangana , India .

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