Lab 4 sarcoidosis and syhilis without audio [Autosaved].pdf

practical lab sarcoidosis and syhilis

1. Lab 4: Sarcoidosis
Syphilis

2. Sarcoidosis
•Definition:
*Chronicmultisystemdiseaseofunknown
causescharecterizedbyàwidespreadnon-
caseatingnoncaseatingepithelioid
granulomasinaffectedtissues.
•

3. Sarcoidosis
•Histopathologicalfeatures:
TightroundedSarcoidgranulomacomposedof:
1-Epithelioidcells
2-Multinucleatedlanghansgiantcells.
3-Peripheral ring of T lymphocytesforming narrow outer zone (Bare granuloma ).
•Giant cellscontain inclusion bodies, as:
1-Crystalline inclusions are composed of calcium carbonate Schaumanbodies
2-Star-shaped asteroid bodiesstain pink with eosin.

4. Sarcoidosis

5. Sarcoidosis

6. Sarcoidosis

11. D.D from T.B. lesion
-Non-caseatinggranuloma.
The granuloma is surrounded by little
lymphocytes, less than that of T.B.
granuloma (bare granuloma)
-The granuloma contains few giant cells
with intracytoplasmicinclusion bodies
(Asteroid and Schuman bodies).
-

12. SYPHILIS
Definition:Infectivegranulomacaused
byspirochaetecalledTreponema
pallidum.
.

13. Types and stages of syphilis
§Acquired
1-Primary Stage
2-Secondary Stage
3-Latent Stage
4-Tertiary Stage

14. Syphilis Curriculum
15

15. §Primary syphilis
§Chancre
§Syphilitic Ulcer:
1-Painless.
2-Very infective.
3-Round or irregular in shape.
4-sharp (punched out ) edge.
5-Dull red clean floor.
Healingof the chancre occurs without treatment in
few weeks [3-8w] àthin and cigarette paper-like
scar

16. (Chancre of mouth

17. §Chancre
§Syphilitic Ulcer:
1-Painless.
2-Very infective.
3-Round or irregular in shape.
4-sharp (punched out ) edge.
5-Dull red clean floor.
Healingof the chancre occurs without treatment in
few weeks [3-8w] àthin and cigarette paper-like
scar.

18. §Chancre

19. HeparLobatum(tertiary syphilis):
Gummain internal organs àfibrous tissue à
contracts and distorts the shape of the organ