Laboratory Animal Care.pp t

SSDD

1. Laboratory Animal Care
TECHNICAL UNIVERISTY OF MOMBASA
Animal Health Monitoring

2. Female Male

3. Estrus Detection in Mice
Estrus Non-Estrus
swollen, moist closed vaginal
and open appearance opening
of Vaginal opening.

4. Normal Females with
Copulatory Plugs
Copulatory plugs is
made of several
different
components---sperm,
ejaculate fluids, and
mucus are primary
substances that
harden within the
cervix.( Hard Waxy)

5. Healthy
Mouse

6. Normal Rat

7. Normal Mouse Normal

8. Sick Mouse
Hunched posture Hunched posture

9. Signs of Pain and Distress in
Rodents
•Decreased activity
•Unkempt fur (not grooming)
•Pilo – erection
•Hunched posture
•Rapid shallow Breathing
•“ Red tears “ albino rats”
•Squinting of eyes
•Vocalization
•Feed and/or water refusal
•Weight loss

10. Alopecia
Hair loss
•Due to excessive grooming
•Metabolic dysfunctions
•External parasites and Nutritional disorders

11. Facial Barbering Agouti (brown mouse)
•Dominant male chews off the hair from head,
neck and back of the less dominant cage
mate

12. Barbering vs Shaved
Barbered
Shaved

13. Ulcerative Dermatitis Syndrome
•Usually in black mice of a C57BL/6 background.
•Mice will develop a dermatitis with alopecia and skin ulcers.
•Mice will scratch at the effected region until ulcers form.
 
•The ulcerated areas often scar, causing restriction of limb
movement.
•Any skin lesions should be brought to the attention of vet
services.

14. Mild Dermatitis

15. Mild Dermatitis
Early Detection is Important!

16. Dermatitis

17. More Severe Dematitis….

18. Too Much Caladryl !

19. Fight wounds

20. Fight Wounds
Fighting is usually seen in males. The wounds are often seen on
the tail, backs and genital area.

21. It is important to note fight wounds EARLY,
Before they turn into….

22. Urine Scalding

23. Dystocia = difficult birth
•This is when a female has difficulty giving
birth.
•Signs might include vaginal discharge,
dehydration, and lethargy.
•Normal mice give birth only at night – if
they are in labor during day , something is
wrong.
•There may also be dead pups in the cage.
•Normal birth times = 1 – 3.5 hours for a
litter of 11 pups

24. Vaginal Prolapse

25. Vaginal prolapse and ulcerative
dermatitis

26.  
Rectal prolapse

27. Penile Prolapsed
 
Alopecia!

28. Do you think this mass is too big?
YES! It impedes movement

29. Mass in
scrotal area

30. Mass with open lesion

31. Lesions on bottom surfaces of paws
due to Burns

32. Would you say this mouse is pregnant?
What if I told you that this mouse is a….

33. A
MALE!!

34. Head Tilt

35. Irritated eye with discharge

36. Did you also note his
irritated eye?

38. Severe Malocclusion

39. Trimming Malocclusion

40. Is there anything wrong with this mouse?

41. Hydrocephalus vs Normal

42. Ringtail (Tail Constriction)

43. Ringtail
Possible cause Low Humidity

44. Is there a difference here?

45. Healthy vs. Sick
Look at:
1.Eyes
2.Ears
3.Tail

46. Porphyrin in Rats (red tears)
Porphyrin is naturally secreted, and normally groomed
away and not seen in most instances.

47. Protruding eye = Exophthalmic
      

49. Rabbit Swollen foot

50. Step 1
Post Examine Cage sticker on Cage

51. Step 2
Fill out Request for Exam Form

52. Step 3
Vet Services will post Examine
Cards on Cage after Assessment.

53. Animals Recovering from Surgery
Blue cards

Date: ___________ Procedure: ___________________

Animal Under
Observation

PI: _________________________

Protocol: ____________________

Account: _____________________

NO Abbreviations for
Procedures!!!

54. Your help in caring for all the
animals at LASC is greatly
appreciated!