Lasix Tablets (Generic Furosemide Tablets)

Lasix (Generic Furosemide tablets) is a medicine used to treat fluid build-up (edema) due to heart failure, liver scarring, or kidney disease. This medicine is also used for the treatment of high blood pressure.
Lasix tablets are used for the treatment of fluid retention associated with heart failure, including left ventricular failure, cirrhosis of the liver and renal disease, including nephrotic syndrome.
This medicine is also used for the treatment of mild to moderate hypertension when brisk diuretic response is required. It is used alone or in combination with other anti-hypertensive agents in the treatment of more severe cases.

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Lasix Tablets (Generic Furosemide Tablets)

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Lasix Tablets (Generic Furosemide Tablets)
Lasix (Generic Furosemide tablets) is a medicine used to treat fluid
build-up due to heart failure, liver scarring, or kidney disease.
This medicine is also used for the treatment of high blood
pressure.
Lasix tablets are used for the treatment of fluid retention
associated with heart failure, including left ventricular failure,
cirrhosis of the liver and renal disease, including nephrotic
syndrome.
This medicine is also used for the treatment of mild to moderate
hypertension when brisk diuretic response is required. It is used
alone or in combination with other anti-hypertensive agents in the
treatment of more severe cases.

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Lasix Tablets (Generic Furosemide Tablets)
Active Ingredient
The active ingredient contained in Lasix tablets
is Furosemide. Each uncoated Lasix tablet
contains 40 mg of Furosemide.

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Lasix Tablets (Generic Furosemide Tablets)
Chemical Structure
The structure of Furosemide is given below:

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Lasix Tablets (Generic Furosemide Tablets)
Lasix tablets are manufactured by Sanofi India Limited in
the strength of 40 mg.
( Website: https://www.sanofi.com/ )

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Lasix Tablets (Generic Furosemide Tablets)
Furosemide Tablets – Brand Names
Furosemide tablets are available under
various drug trade names that include
Lasix, Frusemide, Frusenex , Tebemid, Urix
and Salinex.

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Lasix Tablets (Generic Furosemide Tablets)
Uses of Lasix Tablets
Lasix (Generic Furosemide Tablets) is given to help treat fluid retention
(edema) and swelling that is caused by congestive heart failure, liver disease,
kidney disease, or other medical conditions. It works by acting on the
kidneys to increase the flow of urine.
Furosemide is also used alone or together with other medicines to treat high
blood pressure (hypertension). High blood pressure adds to the workload of
the heart and arteries. If it continues for a long time, the heart and arteries
may not function properly. This can damage the blood vessels of the brain,
heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High
blood pressure may also increase the risk of heart attacks. These problems
may be less likely to occur if blood pressure is controlled.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Tablets Dosage

The dosage of Lasix tablets (Generic Furosemide Tablets)
is given below:
Treatment of Edema :
The usual initial dose of Lasix tablets for the treatment of Edema
in adults is 20 to 80 mg given as a single dose. Normally a
prompt diuresis ensues.
In case required, the same dose can be administered 6 to 8 hours
later or the dose may be increased. The dose can be increased
by 20 or 40 mg if required and given not sooner than 6 to 8 hours
after the previous dose until the required diuretic effect has been
obtained.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Tablets Dosage

The dosage of Lasix tablets (Generic Furosemide Tablets)
is given below:
Treatment of Hypertension:
The normal starting dose of Lasix tablets for the treatment of
hypertension in Adults is 80 mg, normally divided into 40 mg
twice a day. The dosage should then be adjusted as per the
therapeutic response of the individual patient. If desired
response is not obtained, other anti-hypertensive agents should
be added. Changes in blood pressure must be carefully monitored
when Furosemide tablet is used with other antihypertensive
drugs, especially during initial therapy.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Contraindications
Lasix is contraindicated in patients with a hypersensitivity to
Furosemide, Amiloride, Sulphonamides or Sulphonamide derivatives,
or any other component of this medication.
Lasix tablets are also contraindicated in patients with anuria or renal
failure with anuria not responding to furosemide, renal failure as a
result of poisoning by nephrotoxic or hepatotoxic agents or renal
failure associated with hepatic coma, Hypovolaemia and dehydration
(with or without accompanying hypotension), Comatose or pre-
comatose states associated with hepatic cirrhosis, Severe hypokalaemia
(severe hyponatraemia), Porphyria and Addison's disease.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Contraindications
Other contraindications include Impaired renal function with a
creatinine clearance below 30ml/min per 1.73 m2 body surface
area, Digitalis intoxication, Concomitant potassium supplements
or potassium sparing diuretics.
Lasix tablets should not be administered to Children and
adolescents under 18 years of age and Breast-feeding women.
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Lasix Tablets (Generic Furosemide Tablets)
Storage Instructions

Lasix (Generic Furosemide Tablets) have to be
stored at controlled room temperature i.e.
from 20°C to 25°C (68°F to 77°F) with
excursions permitted between 15° to 30°C
(59° to 86°F).
Keep this as well as all other medicines away
from children and pets.
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Lasix Tablets (Generic Furosemide Tablets)
Warnings

Hypotension, Hypovolaemia and Severe electrolyte disturbances –
particularly hypokalaemia, hyponatraemia and acid-base
disturbances have to be corrected before Furosemide therapy is
started. Excessive diuresis may result in dehydration and
reduction in blood volume with circulatory collapse and with
the possibility of vascular thrombosis and embolism, usually in
elderly patients.
Sudden alterations of fluid and electrolyte balance in patients with
cirrhosis may precipitate hepatic coma; therefore, strict observation
is necessary during the period of diuresis.
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Lasix Tablets (Generic Furosemide Tablets)
Warnings

Excessive loss of potassium in patients receiving cardiac
glycosides may precipitate digitalis toxicity. Patients should
be advised not to drive a Vehicle or Perform other potentially
hazardous tasks as an undesirable drop in blood pressure
may impair the patient’s ability to concentrate and react.
In case of patients with diabetes, Furosemide may affect the
blood sugar level. The blood sugar level must be checked
regularly as directed and the results shared with the doctor.
The doctor may be required to adjust your diabetes medication
or diet.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Tablets Side Effects
Furosemide (Lasix tablets) side effects are categorized below by
organ system and listed by decreasing severity.
Gastrointestinal System Reactions: pancreatitis,jaundice
(intrahepatic cholestatic jaundice), anorexia,oral and gastric
irritation, cramping, diarrhea, constipation, nausea, vomiting
Systemic Hypersensitivity Reactions: systemic vasculitis,
interstitial nephritis, necrotizing angiitis
Central Nervous System Reactions: tinnitus and hearing loss,
paresthesias, vertigo, dizziness, headache, blurred vision,
xanthopsia
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Tablets Side Effects
Hematologic Reactions: aplastic anemia (rare), thrombocytopenia,
agranulocytosis (rare),hemolytic anemia,leukopenia, anemia
Dermatologic-Hypersensitivity Reactions: exfoliative dermatitis,
erythema multiforme, purpura, photosensitivity, urticaria, rash,
pruritus
Cardiovascular Reaction: Orthostatic hypotension may occur and
be aggravated by alcohol, barbiturates or narcotics.
Other Reactions: hyperglycemia, glycosuria, hyperuricemia,
muscle spasm, weakness, restlessness, urinary bladder spasm,
thrombophlebitis, fever.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Overdose
The clinical picture in acute or chronic Lasix overdose
depends primarily on the extent and consequences of
electrolyte and fluid loss; e.g. dehydration, blood volume
reduction, hypotension, electrolyte imbalance, cardiac arrhythmias,
hypokalaemia and hypochloraemic alkalosis, and extensions of its
diuretic action.
Symptoms of Lasix overdose can include Decreased urination,
drowsiness, increase in heart rate, irregular heartbeat, irritability,
mood changes, muscle cramps, numbness, tingling, pain, or
weakness in the hands, feet, or lips, rapid breathing, seizures,
sunken eyes, thirst, trembling, weak pulse, weakness and
heaviness of the legs and wrinkled skin.
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Lasix Tablets (Generic Furosemide Tablets)
Treatment of Lasix Overdose
No specific antidote to Lasix is currently known. If ingestion has
only just taken place, attempts may be made to limit further
systemic absorption of the active ingredient by measures such as
activated charcoal.
Treatment of Lasix overdosage is supportive and consists of
replacement of excessive fluid and electrolyte losses.
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Lasix Tablets (Generic Furosemide Tablets)
Lasix Tablets During Pregnancy
Furosemide (Lasix Tablets) is classified by the US FDA as
Pregnancy Category C.
Furosemide has been shown to cause unexplained maternal
deaths and abortions in rabbits at 2, 4 and 8 times the maximal
recommended human dose. There are no adequate and well-
controlled studies in pregnant women. Lasix should be used
during pregnancy only if the potential benefit justifies the
potential risk to the fetus.
Treatment during pregnancy requires monitoring of fetal growth
because of the potential for higher birth weights.
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Lasix Tablets (Generic Furosemide Tablets)
For more details on
Lasix Tablets click here
Lasix Tablets (Generic Furosemide Tablets) by Sanofi India
Limited.
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