Lecture-13 T-Cell Development and Activation.ppt

The development of T cells involving positive and negative selection and MHC restricted development of T cells in thymus are elaborated

1. Prof. Sreerama Krupanidhi
Email: [email protected]

2. T- cell development
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3. 1.To familiarize with T cells
2.To know the maturation of T
cells
3.To distinguish between Th and
Tc cells
4.To acquaint with the sites of T-
cells origin
5.To appreciate thymic schooling
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4. 1.The development of T cells
involving positive and negative
selection will be known.
2.MHC restricted development of
T cells in thymus will be
known.
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5. Blood cell precursors originate
in yolk sac and liver
In postnatal life, the stem cells
reside in the bone marrow
Stem cells differentiate into
cells of erythroid, myeloid or
lymphoid series
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11. Stem cells initially do not express CD4
and CD8 (Double Negative)
Later they express both (Double Positive)
Double positive cell will differentiate into
CD4 positive cell if it contacts a cell
bearing Class II MHC protein, but will
differentiate into CD8 positive cell if it
contacts a cell bearing Class I MHC
proteins
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12. Main Functions Cytokine Mediating That
Function
Activates the antigen
specific helper T cell to
produce a clone of these
cells.
IL-2
Activates cytotoxic T cells.IL-2
Activates B cells. IL-4 and IL-5
Activates Macrophages. Interferon Gamma
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18. Macrophage
Fibroblasts Endothelial cells
Stem cells
Hematopoiesis
Mast cell
Eosinophil
NK cell
LAK cell
Cytotoxic
T cell
T helper cell
B cell
Plasma cells
Antibodies
Neutrophil
Inflammation
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19. Blood cell precursors originate in yolk sac and
liver and transform to bone marrow during
postnatal life.
Double negative T cells become double positive
naïve T cells
T-cells undergo negative selection and positive
selection and develop as naïve Th and Tc cells.
T cells development is MHC restricted.
T cells are master Immune cells
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20. Where from the name T came for T
cells?
Indicate the CDs gradually added
to developing T cell.
Elaborate on T cell differentiation.
Explain Thymic schooling.
What are CD4 and CD8?
Explain Positive and Negative
Selection of T cells?
Study Questions
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21. We acknowledge online
resources/public domains for
the use of the content to develop
teaching material.
Acknowledgements
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Prof. Sreerama Krupanidhi