Lecture - 18 Bromometry.pptx

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1. Bromatometry Lecture - 18 Subject – Pharmaceutical Analysis-I Course – B. Pharm 1 st Year Faculty Name – Umesh Kumar

2. Contents Bromatometry Principle Applications

3. BROMATOMETRY (POTASSIUM BROMATE TITRATION): The specific titrations with potassium bromate is referred to as Bromatometry . It may be exploited as an effective and useful oxidizing agent in the qualitative determination (assay) of pharmaceutical substances like mephenesin , phenol sodium and salicylate.

4. Principle: Potassium Bromate is a powerful oxidizing agent which is reduced smoothly to bromide in the presence of HCl and which is then oxidized to give free bromine by bromate (excess ). At the end point of titration free bromine appears . In this type of titrations Methyl red indicator is used, which decolorises by oxidation at end point.

5. APPLICATIONS: Assay of Isoniazid Determination of Hydroxylamine Determination of As/ Sb

6. Conti…….. To be continued in Next video