Lecture 19- Development of cerebrum & cerebellum 2013.ppt

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1. DEVELOPMENT
of
CEREBRUM
&
CEREBELLUM

2. INTRODUCTION
By the
beginning of
the 3
rd
week of
development,
three germ cell
layers become
established,
ectoderm,
mesoderm and
endoderm.

3. •During the middle of the 3rd week,
the dorsal midline ectoderm
undergoes thickening to form the
neural plate.
•The margins of the plate become
elevated, forming neural folds.
•A longitudinal, midline depression,
called the neural groove is
formed.
•The 2 neural folds then fuse
together, to form the neural tube.
•Formation of the neural tube is
completed by the middle of the
fourth week of development.
EARLY DEVELOPMENT

4. Neural Tube Development
Three-vesicles stage (End of 4
th
Week)
The cranial part of neural
tube dilates to form
brain vesicle. The caudal
part remains narrow and
cylindrical to give spinal
cord
The brain vesicle grows
and gives 3 dilatations
named as:
• Prosencephalon
• Mesencephalon
• Rhombencephalon

5. Neural Tube Development
Five-vesicles stage (5
th
week)

6. Brain Flexures
•Later Pontine flexure appears in
the hindbrain, in the opposite
direction, resulting in stretching
and thinning of the roof of the
hindbrain. 
By 4th week::

The neural tube grows rapidly and The neural tube grows rapidly and
bends ventrally with the head fold, bends ventrally with the head fold,
producing two flexures:producing two flexures:
Midbrain (cephalic) flexure:
between the forebrain & the the
midbrain.midbrain.
Cervical flexure: between the hind etween the hind
brain & the spinal cord.brain & the spinal cord.
FBFB
MBMB
HBHB
HBHB

7. Differentiation of Forebrain Vesicle

The (prosencephalon) The (prosencephalon)
or the forebrain vesicle or the forebrain vesicle
differentiates into:differentiates into:

a a median part, the part, the
diencephalon, and , and
two lateral cerebral
vesicles or
(telencephalic
vesicles.)

The lumen gives the The lumen gives the 3
rd

ventricle and the 2 2
lateral ventricles..

Both cavities Both cavities
communicating with communicating with
each other through a each other through a
large large interventricular
foramen.

8. Development of the Cerebrum
The cerebrum develops from the Telencephalon

9. Development of the Cerebrum

The cerebral The cerebral
hemispheres first hemispheres first
appear on the day appear on the day 3232
as a pair of bubble-as a pair of bubble-
like outgrowths of the like outgrowths of the
Telencephalon. Telencephalon.

By 16 weeksBy 16 weeks, the , the
rapidly growing rapidly growing
hemispheres are oval hemispheres are oval
in shape and cover in shape and cover
the diencephalon. the diencephalon.

10. 
The cerebral The cerebral
hemispheres expand in hemispheres expand in
all directions.all directions.

Its Its medial wall becomes becomes
thin, flat and it is the site thin, flat and it is the site
of of choroid plexus of the
lateral ventricle.
The wall of the telencephalon is formed of 3 layers:
•Ependyma: lining the cavity of the lateral ventricle.
•Mantle layer: Intermediate layer contains nerve cells (grey matter).
•Marginal layer: Outer layer contains nerve fibers (white matter).
As development proceeds most of the nerve cells in the mantle layer
migrate to the outer aspect of the marginal layer to form the
cerebral cortex. The remaining cells (which do not migrate) form
the basal ganglia.

11. By the end of the 3
rd
month the surfaces of the cerebral
hemispheres are smooth. By the 4
th
month the grey matter grows
faster than the white matter with the result that the cortex becomes
folded into gyri separated by sulci. The gyri and sulci effectively
increase the surface area of the brain. The detailed pattern of gyri
& sulci varies somewhat from individual to individual

12. •The basal ganglia
appears in 6
th
week
in the floor of each
cerebral
hemisphere.
•The cerebral cortex
differentiates and the
fibers passing to and
from it, pass through
the basal ganglia,
dividing it into
caudate & lentiform
nuclei (corpus
striatum).
•This fiber pathway
forms the internal
capsule.

13. •Also the
caudate
nucleus
elongates
and
assumes
the shape
of the
lateral
ventricle
and
remains
related to it.
Further expansion Further expansion
of cerebral of cerebral
hemisphere givehemisphere give C- C-
shape shape to theto the
hemisphere hemisphere itself as itself as
well as thewell as the lateral lateral
ventricle.ventricle.

14. Development of the Cerebral Commissures
•As the cerebral cortex
develops, group of fibers,
the commissures, connect
the corresponding regions
of the cortex in the two
hemispheres.
•These are:
•Lamina terminalis.
•Optic chiasma.
•Anterior commissure.
•Posterior commissure.
•Hippocampal
commissure.
•Habenular
commissure.
•Corpus callosum.

15. The cortex
covering the
surface of the
corpus striatum
grows relatively
slowly, so it is
overgrown by
the rest of the
hemisphere and
lies in the
depth of the
lateral sulcus.
This is the the
insula.insula.

16. Development of the Cerebellum
It develops from the dorsal part of the alar plate
of the Metencephalon
metencephalonmetencephalon
myelencephalonmyelencephalon

17. Development of the Cerebellum
Pontine flexure results in:
1.Moving the alar
plates laterally
2.Stretching and
thinning of the roof
plate
3.Widening of the
cavity to form the
4
th
ventricle
The metencephalon
develops into pons
and cerebellum.

18. •The dorsal parts thicken to
form Rhombic lips, , that gives that gives
rise torise to the cerebellum.
•Some neuroblasts migrate
from the mantle layer to the
marginal layer and form the
cerebellar cortex. .
•Others remains in the
mantle layer and give rise to
the cerebellar nuclei.
•The cerebellar peduncles
develop later as the axons of
the neurones of the
cerebellar nuclei grows out
to reach the brain stem.
Metencephalon: Changes in Alar plates

19. •As the cerebellar
hemispheres develops they
undergo a complicated
process of transverse folding
and form closely packed,
leaf-like transverse gyri
called folia.
•These processes of fissure
formation and foliation
continue throughout
embryonic, fetal, and
postnatal life, and they vastly
increase the surface area of
the cerebellar cortex.
50 d
35 d
150 d
90 d

20. Congenital Anomalies of Brain
•Mental retardation.
•Seizures.
•Cerebral palsy.
•Cranium bifidum with or
without meningocele &
meningoencephalocele.
•Meroanencephaly.
•Microcephaly.
•Agenesis of corpus
callosum.
•Hydrocephalus.
•Arnold-Chiari
malformation.
•Anencephaly.
Anencephaly