Lecture 3 - biomedical applications of nanotechnology

Controlling and manipulating matter on the nanometer-length scale (1-100 nm), and
Exploiting novel phenomena and properties (physical, chemical, biological, mechanical, electrical) at the nanoscale.

1. Biomedical Applications of Nanotechnology

2. What is Nanotechnology? The creation of useful, functional materials, devices, and systems through: Controlling and manipulating matter on the nanometer-length scale (1-100 nm), and Exploiting novel phenomena and properties (physical, chemical, biological, mechanical, electrical) at the nanoscale.

3. Potential market for nanotechnology ? $1 trillion business within the next 10 to 15 years.

4. Nanotechnology in Medicine Biological imaging for medical diagnostics. Advanced drug delivery systems. Biosensors for airborne chemicals or other toxins. Regenerative medicine: More durable, rejection-resistant artificial tissues and organs. NANOMEDICINE

5. Targeted Drug Delivery

6. Risk Factors Cardiovascular Disease Neurological Disorder Inflammation Obesity / Diabetes Tumor Angiogenesis / Metastasis Nanotechnology

7. Development of In Vivo and In Vitro Inflammatory Disease Models

8. In Vivo Brain Inflammation Models Environmenta l Toxicant s - Mediated Brain Inflammation. Bacterial Infection-Mediated Brain Inflammation.

9. Environmental Toxicants & Brain Inflammation C57/BL6 Mouse Chlorpyrifos [OP Pesticide] Determination of pro-inflammatory mediators Cytokines: TNF-  , IL-1  , IL-6 Chemokine: MCP-1 Adhesion molecules: E-selectin, ICAM-1, VCAM-1 Isolation of brain regions

10. Bacterial Infection & Brain Inflammation C57/BL6 Mouse Lipopolysaccharide [LPS] Isolation of brain regions Determination of pro-inflammatory mediators Cytokines: TNF-  , IL-1  , IL-6 Chemokine: MCP-1 Adhesion molecules: E-selectin, ICAM-1, VCAM-1

11. In Vitro Brain Inflammation Models Brain Microvascular Endothelial Cells (BMEC) Astrocytes Microglia

12. Determination of pro-inflammatory mediators Cytokines: TNF-  , IL-1  , IL-6 Chemokine: MCP-1 Adhesion molecules: E-selectin, ICAM-1 Pro-inflammatory Stimuli-Mediated Inflammation in Brain Cells Pro-inflammatory Stimuli [100 ng /m L of LPS] Culture Media Brain Cells

13. (Biology- NanoChemistry -Drug Discovery) Approach Developing the goodness of animal models comprises three objects

14. (Biology- NanoChemistry -Drug Discovery) Approach In biological webs, molecular ingredients can be genes, drugs, proteins, metabolites, or even ailments and phenotypes

15. (Biology- NanoChemistry -Drug Discovery) Approach Early drug invention discussed “magic bullets”

16. (Biology- NanoChemistry -Drug Discovery) Approach Around 90 percent of the medications planned following this model

17. (Biology- NanoChemistry -Drug Discovery) Approach Th e clar i f i ca t i o n of small-molecule che c k s th a t s h ed light on primary and illness-associated biological incident

18. (Biology- NanoChemistry -Drug Discovery) Approach Awareness of nanomaterial– biological reciprocal actions

19. (Biology- NanoChemistry -Drug Discovery) Approach Compilation of this information will permit for the definition

20. (Biology- NanoChemistry -Drug Discovery) Approach Nanomaterials can have distinguished health impacts

21. Youtube Link: I am giving video clip but youtube serves better video clips related with our class, nanochemistry . Please watch these clips with care. And submit your report on these video clips; For what you have learned . https:// www.youtube.com/watch?v=5GJLmwtBgDA