Lecture Schedule for 2ND MBBS Exam & Revision 24_25.docx

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1. ALEX EKWUEME FEDERAL UNIVERSITY, NDUFU-ALIKE
COLLEGE OF MEDICAL SCIENCES
FACULTY OF BASIC MEDICAL SCIENCES
DEPARTMENT OF MEDICAL BIOCHEMISTRY
200 LEVEL FIRST SEMESTER
Course Code/Title/Credit Units Topic(s) DurationCourse Lecturer
MBC 201: Introduction to Medical
Biochemistry, 2 Credit Units
Biochemistry and Medicine, Roles and Inter-relationship6 Dr. C.A. Famurewa
Chemical Kinetics and Order of Reactions 6 Mr G. O. Ufebe
Organic Reactions 6 Dr. R. A. Eyo
The Physical and Chemical Properties of Water, The Roles
of Water
6 Prof. S.O. Elom/Mr.
O. G. Ufebe
Acid-Base Chemistry, Buffers and pH 6 Mrs C. Benneth-
Ugochukwu
MBC 211: Chemistry of Biomolecules, 3
Credit Units
Structure, Properties and Functions of
Carbohydrates
6
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Dr. R. A. Eyo
Structure, Properties and Functions of Amino
Acids and Proteins
6 Dr C. A. Famurewa
Structure, Properties and Functions of Nucleic Acids and
Nucleotides
6 Mr G.O. Ufebe
Structure, Properties and Functions of
Lipids
6 Dr C. Aloke
Membrane Structure, Properties and
Functions
6 Dr C.O. Egwu
MBC 291: Medical Biochemistry
Practicals I, 1 credit
Preparations of different types of buffers Mr O. G. UfebePRACTICAL
DEMONSTRATORS
Mrs O. Obasi
Test for carbohydrates Dr C. Aloke Mrs G. I. Elom
Test for proteins Dr C.O. Egwu Ms N. Ituma
Test for nucleic and acids Dr G. N. OnyejiMrs O. Obasi
Test for lipids
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Dr. C. A Ms A. Babamutuwa
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2. Famurewa
Membranes Mrs C. Benneth-
Ugochukwu
Mrs G. I. Elom
Recent advances in Enzymology 2 Dr C. O. Egwu Mr Obasi E
200 LEVEL SECOND SEMESTER
MBC 222: Bioenergetics and Enzymology, 2 Credit Units
Lecture TopicsFlow of Energy
and
Matter through the
Biosphere
Elementary
thermodynamic
Systems, laws of
thermodynamics
Standard Free
Energy,
Enthalpy,
Entropy and
Interrelationship.
Energy
transformations
And coupling,
ATP as the
universal carrier
of energy, other
compounds
And nucleoside
tri-
Phosphates in
the transfer of
high energy
phosphates.
Oxidation-
Reduction
reactions,
reduction
potentials,
standard
reduction
potential and its
measurement.
Medical
enzymology,
enzymes and
kinetics
Use of enzymes
in Medicine
Duration (h) 3 5 5 5 3 2
Lecturer Dr. C.O. EgwuDr M. O. EjiProf. C.E.C.C
Ejike
Dr R.A. Eyo Dr I. IgwenyiDr. C.O. Egwu
MBC 232: Metabolism and Biosynthetic Pathways, 3 Credit Units
Lecture Digestion andHaem Chemistry Metabolism of Metabolism of Lipids Metabolism of Nucleic Acids
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3. Topics Absorption and Porphyrin
biosynthesis,
Inborn errors of
porphyrin
Metabolism
carbohydrates
and its inborn
errors.
and its inborn errorsAmino acids and
its
Inborn errors.
Metabolism and
its inborn errors
Duration (h) 3 6 6 6 6 6
Lecturer Dr M.O. Eji
©
Mr. G. UfebeDr. I. O.
Igwenyi
Dr. R. A. Eyo Mr. O. G. UfebeProf. S. O. Elom/
Mr. G. Ufebe
MBC 292: Medical Biochemistry Practicals II, 1 Credit Unit

Practicals’ Topics Supervising Lecturers
1. Fractionation of Plasma Proteins
2. Qualitative test for Protein
- Biuret test for proteins
- Folin Ciocalteau test for proteins
3. Qualitative and quantitative determination of amino
acids
- Ninhydrin method
- Spot test for amino acids
4. Solubility and Isoelectric
points proteins
5. Test for proteins in Urine
- Turbidiometric tests
- Sulfosalicy test
- Coaglatiion test
Dr M.O. Eji
Dr R.A. Eyo
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6. Test on Lipids
- Solubility test
- Lipid extraction
7. Separation of Lipid
Components
- Thin layer chromatography (TLC)
- Test for phospholipids
Dr C.O. Egwu
Mr. G.O Ufebe
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4. 300 LEVEL FIRST SEMESTER
MBC 301: INTRODUCTION TO CLINICAL BIOCHEMISTRY, 2 Credits
Lecture
Topics
Liver and Renal
Function Test
Blood chemistry
and blood functions
including clotting
mechanisms
Molecular basis
of diseases
Diagnostic and
therapeutic
enzymology
Hemoglobinopathies Other body fluids including
cerebrospinal fluid, synovial,
aqueous and, vitreous humours,
intestinal fluid, lymph, tears and
semen, their chemistry and
functions.
Duration
(h)
3 5 5 5 3 2
Lecturer Dr D. ObasiDr C. A FamurewaDr. I.O. IgwenyiDr D. ObasiDr C. A Famurewa
©
Dr M. Eji
MBC 331: INTRODUCTION TO MOLECULAR BIOLOGY, XENOBIOTICS AND FORENSIC BIOCHEMISTRY, 2 Credits
Lecture TopicsDNA metabolism, replication,
repairs and recombination,
transcription, reverse
transcription, regulation of
transcription, operons, post-
transcriptional processing of
RNA and DNA.
Regulation
of gene
expression
Protein synthesis;
genetic code,
initiation,
elongation and
termination of
protein synthesis,
post translation
processing, action
of antibiotics in
protein synthesis
Metabolism of foreign
compounds
(xenobiotics)/drugs: phase I
and II reactions. Microsomal
and non-microsomal
enzymes. Cyt P450 and other
drug metabolizing enzymes
(DMES). Detoxification and
excretion of foreign
substances
Forensic biochemistry: Adulteration
of foods, drinks and drugs. Quality
control of foods and drugs.
Contamination of foods and drugs.
Forensic and toxicology
examinations. Determination of toxic
substances in foods, environment,
body fluids and tissues. Biochemical
mechanisms in toxicology
Duration (h) 3 6 6 6 6
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5. Lecturer Prof Ejike Prof EjikeDr. C. Aloke Dr C. Aloke
©
Dr P.Ujong
MBC 341: NUTRITIONAL BIOCHEMISTRY, 2 Credits
Lecture TopicsFoods and nutrients,
biomedical
importance, types and
composition of food.
Food plan and
essentials of diet,
energy expenditure
and basal metabolic
rate, mutagens and
antimutagens in food.
=Lipoprotein
associated diseases,
cholesterol and
cardiovascular
diseases.
Under nutrition and
starvation nutritional
pathology/disorders:
kwashiorkor,
marasmus, obesity
Nutrition requirements
of special groups:
pregnant women,
lactating mothers,
alcoholics. Nutrition
and infections
Vitamins-
liposoluble
and
hydrosoluble.
Minerals
Co-enzymes,
structure and
functions
Duration (h) 6 33 6 6 6
Lecturer Prof H. Uro-ChukwuProf H. Uro-ChukwuProf Ejike Dr M. Eji
©
Dr. M. Eji Dr. P. Ujong
MBC 343: SPECIAL TOPICS IN BIOCHEMISTRY, 2 credits
Lecture
Topics
Endocrinology,
structure, functions
and molecular
mechanism of action
of steroid, thyroid and
polypeptide
hormones
Immunochemistry:
molecular basis of
immunoglobulins,
antigen-antibody
interactions,
immunological
laboratory methods
Neurobiochemistry:
brain biochemistry-
the neuron, structure
composition and
metabolism.
Neurohumoural
transmission,
regulatory mechanism
Introduction to
recombinant DNA
technology:
methods of gene
amplification PCR
and cloning
techniques. The
biology of HIV
infection
Biochemical
endocrinology:
general consideration
of endocrine systems,
chemistry and
biochemical effects of
thyroid/parathyroid
hormones, hormones
of the gonads and
adrenal glands. The
pancreatic hormones.
Hormones of the
hypothalamus and
pituitary gland. Recent
advances in studies of
hormonal and nervous
system regulation of
biochemical mechanism
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6. Duration
(h)
6 6 6 6 6
Lecturer Dr I. O. Igwenyi Dr D Obasi Mr G. O. Ufebe
©
Dr. C. Aloke Dr. R. A. EyoDr. R. A. Eyo
MBC 391: PRACTICAL BIOCHEMISTRY III, 1 Credit
Lecture TopicsBiochemical
aspects of
diagonosis and
therapeutics
Body fluid
homeostasis
and related
conditions.
The chemical basis
to techniques in
clinical
biochemistry
Biochemical
mechanisms in
clinical
biochemistry
Duration (h) 5 5 5 5
Lecturer Dr C. O Egwu
©
Dr . EjiMr. O. Ufebe Dr. R.A. Eyo
Practical
Demonstrators
Ms N. ItumaMrs O. ObasiMs Babamutuwa A Mr Obasi E/Mrs
I. Elom
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