LIPID PROFILE: VARIATIONS PREDISPOSING TO COMMON CLINICAL DISORDER

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1. LIPID PROFILE VARIATIONS PREDISPOSING TO COMMON CLINICAL DISORDER PBL WRAP-UP SESSION 3 rd Group : E AUG,2017 th batch. 5/31/2018 1

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3. INTRODUCTION Lipids are group of organic substance of fatty nature which are insoluble in water, soluble in fat solvents and which are related to fatty acids. 5/31/2018 3

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6. Plasma lipid profile Analyte Reference value Total plasma lipids 400–600 mg/ dL Total cholesterol 140–200 mg/ dL HDL cholesterol, male 30– 60 mg/ dL HDL cholesterol, female 35– 75 mg/ dL LDL cholesterol, 30-39 years 80–130 mg/ dL Triglycerides, male 50–150 mg/ dL Triglycerides, female 40–150 mg/ dL Phospholipids 150–200 mg/ dL Free fatty acids 10 – 20 mg/ dL 5/31/2018 6

7. SIGNIFICANCE OF LIPID PROFILE TEST Screening for primary and secondary hyperlipidemias Monitoring for risk of atherosclerosis Monitoring treatment of hyperlipidemias 5/31/2018 7

8. SERUM CHOLESTEROL LEVEL INCREASED Secondary hyper lipoproteinemia Diabetes mellitus Hypothyroidism Nephrotic syndrome Liver disease Chronic alcoholism DECREASED Severe liver damage Hyperthyroidism Malnutrition Hypobetalipoproteinemia Tangier’s disease Chronic anemia 5/31/2018 8

9. TRIGLYCERIDE LEVEL INCREASED Familiar hypertriglyceridemia Von gierke disease Diabetes mellitus Hypothyroidism Nephrosis DECREASED Malnutrition Recent weight loss Vigorous exercise Drugs 5/31/2018 9

10. HDL CHOLESTEROL LEVEL INCREASED Moderate consumption of alcohol, insulin and estrogen Hyper alpha lipoproteinemia Hypo beta lipoproteinemia DECREASED Stress Acute MI Stroke Hypothyroidism Starvation 5/31/2018 10

11. LDL CHOLESTEROL INCREASED Familiar hypocholestrolemia Familiar combined hyperlipidemia Diabetes mellitus Hypothyroidism Nephrosis Chronic renal failure DECREASED Severe illness Certain drugs A beta lipoproteinemia 5/31/2018 11

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