Liposomes ppt

liposomes micro structural drug delivery system

1. LIPOSOMES DRUG DELIVERY SYSTEM Prepared By Miss. Mane Deshmukh P.P . Guided By Mrs. Barhate A.N. SVPM’S COLLEGE OF PHARMACY MALEGAON (BK) 1

2. Introduction Definition Formation of liposome Structural components Composition of liposomes Classifications Advantages & disadvantages Preparation methods Limitations of liposomes technology Characterization of liposomes Applications Marketed Preparations References Contents 2

3. INTRODUCTION 3

4. Definition 1,16 :- “Liposomes are defined as structure consisting of one or more concentric spheres of lipid bilayers separated by water or aqueous buffer compartments”. 4

5. FORMATION OF LIPOSOME s 19,20 :- 5

6. STRUCTURAL COMPONENT 3,12-13 :- 6

7. Phospholipids Sphigolipids Cholesterols Polymer material Polymer lipids Bearing Cationic lipids Other substance Composition OFLiposomes 13 :- 7

8. CLASSIFICAT ION 8-18 :- 8

9. 9

10. Classes of Liposomes 12 :- 10

11. 11

12. It should be biodegradable, biocompatible, and flexible. It can carry both water and lipid soluble drugs. The drugs can be stabilized from oxidation. It should be improve the protein stabilization. It provides controlled hydration,sustained release, targeted drug delivery or site specific drug delivery. Stabilization of entrapped drug from hostile environment . Alter pharmacokinetics and pharmacodynamics of drugs . It can be administered through various routes. It can incorporate micro and macro molecules Advantages 10-18 :- 12

13. It has stability It has solubility It has short half life The phospholipids undergoes oxidation, hydrolysis Leakage and fusion It is high production cost Some time allergic reactions may occur to liposomal constituents Disadvantages 10-18 :- 13

14. PREPARATION METHODS 1-8,12-16 :- 14

15. 15

16. 2 16

17. MECHANICAI DISPERSION METHOD : 17

18. FRENCH PRESSURCELLS(ULV/OLV):- 18

19. FREEZE THAW SONICATION (FTS):- 19

20. SOLVANT DISPERSION METHOD:- 20

21. 21

22. 22

23. LIMITATIONS OF LIPOSOMES TECHNOLOGY (15) :- 23

24. 24

25. 25

26. 26

27. 27

28. 28

29. 29

30. 30

31. CHARACTERIZATION 11-13 :- 31

32. 32

33. APPLICATIONS:- 33

34. 34

35. MARKETED PREPRATION 21-22 :- 35

36. REFERANCES :- 1) Aulton ME. Pharmaceutics-The science of dosage form design, 2002, 2 nd edit. 2) Banker S. Modern pharmaceutics, 2009, vol.121, 4 th edi., 275 3) Vyas S.P. & Khar R.K. “Targeted & controlled drug delivery : Novel carrier system”. CBS publishers and distributors, 2007. 4) Ansels ,Pharmaceutical dosage forms& Drug delivery system,8 th edi. 36

37. 5) Lidgate DM, Felgner PL, In vitro and in vivo studies evaluating a liposome system for drug solubilisation. Pharm Res 1988; 5: 759–764. 6) P, Bilandi A, Akanksha M, Kapoor B, Seth GL, BihaHimanshu A, Sitasharan P, Singhai AK: Liposomes as drug carriers. Int J Pharm Liposomes System 2011, 2(7):945–951. 7) Kataria S, Sandhuni SD:Stealth liposomes: a review. Int J Res Art Pharm, 2011, 2(5):1534–1538 8) Jessy S,Vinay B, Novel delivary system.Int.j pharm bio sci 2013 Jan(1):150-160 37

38. 9) Barain, H. & Montazer, M,A Review on Applications of Liposomes in Textil Processing. of Liposome Res, 2008 ; 18 (3) 249-262 10) Anna J,Liposomes,J Pharm Sci. & Res. 2013,5(9) 181- 183 11)Patel N,Panda S,Liposomes drug delivary system.J Pharm Sci Bio Res 2012;2(4):169-175 12) Thulasiramaraju T,Sudhakar b, Liposomes.A Novel drug delivary system.Int J Bio Pharm 2012;3(1):5-16 13) Kulkarni p,Yadav j. Liposomes.A Novel drug delivary system.Int J Curr Peper Res2011 ;3(2),10 38

39. 14) Harashima , H., Sakata, K., Funato , K., Kiwada , H., 1994.Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes.Pharm . Res. 11,402-406. 15) Sharma A.Liposome in drug delivery progress and limitation. Int j pharm. 1997; 154;123-140. 16) Abdus S. Liposome drug delivery system an update review. Current drug delivery.2007; 4; 297-305 17) Mansoori and Agrawal , Liposome drug delivery system ,Int J Art Res Pharm Bio, 2012; Vol.2 (4):453-464 39

40. 18) Shashi K., Satinder K, Bharat P. A Complete Review on Liposomes. Int Res J Pharm 2012;3(7) 10-16 19) Lasic D. Mechanism of liposome formation Journal of liposome research. 1995; 5(3); 431-441. 20) Lasic D. Mechanism of liposome formation .Journal of liposome research.1995; 5(3); 431-441. 21)www.slideshare.com 22) www.authorstream.com 40