Liposomes.pptx

Liposomes

1. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 1/16 Liposomes: The Tiny Saviors Of Modern System PRESENTED BY: J.P.S.R.Lavanya M.Pharm-1-1 st Semister Regd no:222104 Dept. of Pharmaceutics

2. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 2/16 Introduction Composition of liposome Advantages and Disadvantages Classification Methods of Preparation Stability Characterization/ Evaluation Applications and Marketed Preparations References CONTENTS

3. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 3/16 INTRODUCTION Liposomes are concentric bilayered vesicles in which an aqueous volume is entirely enclosed by a membranous lipid bilayer mainly composed of natural or synthetic phospholipids. Liposome were first produced in England in 1961 by Alec D. Bangham The size of a liposome ranges from 20 nm up to several micrometers .

4. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 4/16 Cholesteral alignment between phospholipid bilayer Phospholipids COMPOSITION OF LIPOSOMES Phospholids Phosphoglycerides Sphingolipids 2. Cholesterol

5. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 5/16

6. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 6/16 CLASSIFICATION VESICLE TYPE ABBREVIATION DIAMETER SIZE NO. OF LIPID BI-LAYER Unilamellar Vesicle UV All size range ONE Small unilamellar Vesicle SUV 20-100 nm ONE Medium unilamellar Vesicle MUV >100 µm ONE Large unilamellar Vesicle LUV >1000 µm ONE Giant unilamellar Vesicle GUV >1µm ONE Oligolamellar Vesicle OLV 0.1-1 µm 5 Multilamellar Vesicle MLV >0.5 µm 5-25 Multivesicular Vesicle MV >1 µm Multicompartmental structure

7. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 7/16

8. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 8/16 b) Bath and Probe Sonicator a) Hand Shaking Method Mechanical Dispersion methods

9. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 9/16 c ) French Pressure Cell Freeze SUV dispersion Thaw at room temperature for 15 minutes Sonicate Rupture of SUV’s occur Formation of liposomes d) Freeze Thaw Sonication

10. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 10/16 Solvent Dispersion method a) Ethanol injection method b) Ether injection method

11. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 11/16 c) Reverse Phase Evaporation Vesicles

12. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 12/16 STABILITY

13. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 13/16 CHARACTERIZATION

14. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 14/16 APPLICATIONS Liposomes are drug or protein delivery vehicles. Liposome in antimicrobial, antifungal(lung therapeutics) and antiviral (anti HIV) therapy. In tumour therapy. In gene therapy & in immunology. Liposomes as artificial blood surrogates. Liposomes as radio pharmaceutical and radio diagnostic carriers. Liposomes in cosmetics and dermatology. MARKETED PREPARATIONS Liposome ( Doxil ™) Doxorubicin = Kaposi’s sarcoma Liposome (EVACT ™) = breast cancer Liposome(DaunoXome™) Daunosome = Advanced Kaposi’ sarcoma, small cell lung cancer, leukaemia & solid tumour Liposome ( VincaXome ™) Vincristine = Solid tumour

15. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 15/16 REFERENCES Baviskar D.T. and J ain D.K., Novel drug delivery systems, Nirali Prakashan, pg.no.- 14.15-14.27 Y. Sultana., Liposomal Drug Delivery Systems: An Update Review., Current Drug Delivery 2007, 4, 297-305. Sharma Shailesh, Sharma Neelam, Kumar Sandeep, Gupta GD., Liposomes: A review., Journal of Pharmacy Research 2009, 2(7),1163-1167.

16. Shri Vishnu College of Pharmacy AICTE File No: 730-05-029/P/ET/97 NBA File No: NBA/ACCR-1183/2008., Dt:05-06-09 Ms. J. P. S. R. Lavanya Dept. of Pharmaceutics 2 May,2023 16/16 THANK YOU…..