Lobular Carcinoma In Situ (LCIS)

Breast Cancer, Lobular Carcinoma In Situ, LCIS

1. Lobular Carcinoma In Situ (LCIS) Dr. Mohammed Fathy Bayomy Lecturer of Clinical Oncology Zagazig University

2. Incidence

3. Incidence

4. Characterized by Pathology Small Uniform Dyshesive Cells Expanded Acini Intra-cytoplasmic vacuoles

5. Characterized by Pathology

6. Pleomorphic Classic Classification Pathology (Cont.,)

7. Classification Pathology (Cont.,)

8. Pleomorphic (PLCIS) Pathology (Cont.,)

9. Pleomorphic (PLCIS) (Cont.,) Pathology (Cont.,)

10. Pleomorphic (PLCIS) (Cont.,) Pathology (Cont.,)

11. Pleomorphic (PLCIS) (Cont.,) Pathology (Cont.,) ER -ve PR -ve HER2 +ve

12. Classic (CLCIS) Pathology (Cont.,)

13. Classic (CLCIS) (Cont.,) Pathology (Cont.,)

14. Classic (CLCIS) (Cont.,) Pathology (Cont.,) ER +ve HER2 -ve

15. Investigations Diagnostic Bilateral Mammography Comedo necrosis Microcalcification Pleomorphic subtype

16. Core Biopsy Diagnosis Not Realistic to differentiate between ALH & LCIS

17. Excisional Biopsy Diagnosis (Cont.,)

18. History and Physical exam. Diagnostic bilateral mammography. Pathology review. NCCN guideline for Work-up Diagnosis (Cont.,)

19. Management

20. Management (Cont.,)

21. NCCN guideline for Treatment Core Biopsy Consider Risk Reduction + Surveillance Surgical Excision Excisional Biopsy Classic Pleomorphic Concordant Discordant DCIS Invasive Pure LCIS

22. Tamoxifen Chemoprevention Trials

23. NSABP P-1 Study design

24. NSABP P-1 Result

25. NSABP P-2 (STAR) Study design

26. NSABP P-2 (STAR) Result