Local hormone

local hormone

1. LOCAL HORMONE

2. LOCAL HORMONE Secreted by body tissue to act locally 1) histamine 2) serotonin 3) prostaglandins 4) erythropoietin 5) gastrointestinal hormones

3. histamine Hormone that chemically similar to the hormone serotonin Produce by mast cells and basophils FUNCTIONS : Plays a role in localized immune responses and allergic reaction Increase capillary permeability and vasodilatation Stimulates secretion of gastric juice

4. serotonin It is a neurotransmitter and primarily found in platelet, brain and intestinal wall FUNCTIONS: Causes intestinal secretion and contraction of smooth muscles Blood clotting

5. prostaglandin produced naturally by the body derived from fatty acids, such as arachidonic acid or linoleic acid and they act as mediators FUNCTIONS: Inhibit aggregation Regulating blood pressure Blood clotting Uterine contraction during labour Mediating pain and inflammation

6. erythropoietin Synthesized in the kidneys FUNCTIONS: to promote the differentiation and development of red blood cells and to initiate the production of hemoglobin, the molecule within red cells that transports oxygen.

7. Gastrointestinal hormone Gastrin secretin Cholecystokinin (CCK)

8. GASTRIN Polypeptide hormone secreted by the mucous lining of the stomach FUNCTION: promote gastric juice secretion

9. SECRETIN it stimulates adenylate cyclase activity and converts ATP to cyclic AMP as it combine with secretin receptor reduces acid secretion from the stomach by inhibiting gastrin release from G cell and helps neutralize the pH of the digestive products entering the duodenum from the stomach

10. cholecystokinin mediates a number of physiological processes, including digestion located in the small intestine causes the increased production of hepatic bile stimulates the contraction of the gall bladder and the relaxation of the Sphincter of Oddi

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