Lymphocytes and Chronic Inflammation.pptx

Complete lecture of chronic inflammation

1. Chronic Inflammation

2. Role of Lymphocytes Microbes and other environmental antigens CD4 + T lymphocytes TH1 cells produce the cytokine IFN-γ, which activates macrophages by the classical pathway TH2 cells (Parasitic infection)secrete IL-4, IL-5, and IL-13, which recruit and activate eosinophil's and are responsible for the alternative pathway of macrophage activation TH17 cells secrete IL-17 and other cytokines, which induce the secretion of chemokine's responsible for recruiting neutrophils into the reaction . Tertiary lymphoid organs- All inflammatory cells accumulate

3. Role of Lymphocytes

4. Role of Lymphocytes Eosinophils Parasitic infection, Major basic protein Mast cells Mast cells (and basophils) express on their surface the receptor FcεRI , which binds the Fc portion of IgE antibody . Neutrophils-Acute on chronic

5. Granulomatous Inflammation Granulomatous inflammation is a form of chronic inflammation characterized by: collections of activated macrophages , often with T lymphocytes, and sometimes associated with central necrosis , activated macrophages or epitheliod cells. Langhen cells, inverted U shaped nucleus in macrophages Types Foreign body granulomas Immune granulomas

6. Examples of Diseases With Granulomatous Inflammation